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Precision nutrition-targeted gut microbiota (GM) may have therapeutic potential not only for age-related diseases but also for slowing the aging process and promoting longer healthspan. Recent studies have shown that restoring a healthy symbiosis of GM by counteracting dysbiosis (DYS) through precise nutritional intervention is becoming a major target for extending healthspan. Microbiota-accessible borate (MAB) complexes, such as boron (B)–pectins (rhamnogalacturonan–borate) and borate–phenolic esters (diester chlorogenoborate), have a significant impact on healthy host–microbiota symbiosis (HMS). The mechanism of action of MABs involves the biosynthesis of the autoinducer-2–borate (AI-2B) signaling molecule, B fortification of the mucus gel layer by the MABs diet, inhibition of pathogenic microbes, and reversal of GM DYS, strengthening the gut barrier structure, enhancing immunity, and promoting overall host health. In fact, the lack of MAB complexes in the human diet causes reduced levels of AI-2B in GM, inhibiting the Firmicutes phylum (the main butyrate-producing bacteria), with important effects on healthy HMS. It can now be argued that there is a relationship between MAB-rich intake, healthy HMS, host metabolic health, and longevity. This could influence the deployment of natural prebiotic B-based nutraceuticals targeting the colon in the future. Our review is based on the discovery that MAB diet is absolutely necessary for healthy HMS in humans, by reversing DYS and restoring eubiosis for longer healthspan.
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Title
Microbiota-Accessible Borates as Novel and Emerging Prebiotics for Healthy Longevity: Current Research Trends and Perspectives
Author
Biţă Andrei 1
; Scorei Ion Romulus 2
; Soriano-Ursúa, Marvin A 3
; Mogoşanu, George Dan 1
; Belu Ionela 4 ; Ciocîlteu Maria Viorica 5 ; Biţă, Cristina Elena 6 ; Rău Gabriela 7 ; Pisoschi, Cătălina Gabriela 8 ; Maria-Victoria, Racu 9
; Pinzaru Iurie 9 ; Contreras-Ramos, Alejandra 10
; Kostici Roxana 11 ; Neamţu Johny 12 ; Biciuşcă Viorel 13
; Gheonea, Dan Ionuţ 14
1 Drug Research Center, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349 Craiova, Romania; [email protected] (A.B.); [email protected] (G.D.M.); [email protected] (M.V.C.); [email protected] (G.R.); [email protected] (C.G.P.); [email protected] (R.K.); [email protected] (J.N.), Department of Pharmacognosy & Phytotherapy, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349 Craiova, Romania
2 Department of Biochemistry, BioBoron Research Institute, S.C. Natural Research S.R.L., 31B Dunării Street, 207465 Podari, Romania; [email protected]
3 Department of Physiology, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Diaz Mirón, Mexico City 11340, Mexico; [email protected]
4 Drug Research Center, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349 Craiova, Romania; [email protected] (A.B.); [email protected] (G.D.M.); [email protected] (M.V.C.); [email protected] (G.R.); [email protected] (C.G.P.); [email protected] (R.K.); [email protected] (J.N.), Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349 Craiova, Romania
5 Drug Research Center, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349 Craiova, Romania; [email protected] (A.B.); [email protected] (G.D.M.); [email protected] (M.V.C.); [email protected] (G.R.); [email protected] (C.G.P.); [email protected] (R.K.); [email protected] (J.N.), Department of Instrumental and Analytical Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349 Craiova, Romania
6 Department of Rheumatology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349 Craiova, Romania; [email protected]
7 Drug Research Center, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349 Craiova, Romania; [email protected] (A.B.); [email protected] (G.D.M.); [email protected] (M.V.C.); [email protected] (G.R.); [email protected] (C.G.P.); [email protected] (R.K.); [email protected] (J.N.), Department of Organic Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349 Craiova, Romania
8 Drug Research Center, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349 Craiova, Romania; [email protected] (A.B.); [email protected] (G.D.M.); [email protected] (M.V.C.); [email protected] (G.R.); [email protected] (C.G.P.); [email protected] (R.K.); [email protected] (J.N.), Department of Biochemistry, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349 Craiova, Romania
9 National Agency for Public Health, 67A Georghe Asachi Street, MD-2028 Chisinau, Moldova; [email protected] (M.-V.R.); [email protected] (I.P.)
10 Laboratory of Molecular Biology in the Congenital Malformations Unit, Children’s Hospital of Mexico Federico Gomez (HIMFG), Calle Dr. Marques 162, Col. Doctores, Alc. Cuahutémoc, Mexico City 06720, Mexico; [email protected]
11 Drug Research Center, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349 Craiova, Romania; [email protected] (A.B.); [email protected] (G.D.M.); [email protected] (M.V.C.); [email protected] (G.R.); [email protected] (C.G.P.); [email protected] (R.K.); [email protected] (J.N.), Department of Toxicology, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349 Craiova, Romania
12 Drug Research Center, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349 Craiova, Romania; [email protected] (A.B.); [email protected] (G.D.M.); [email protected] (M.V.C.); [email protected] (G.R.); [email protected] (C.G.P.); [email protected] (R.K.); [email protected] (J.N.), Department of Physics, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349 Craiova, Romania
13 Department of Internal Medicine–Pneumology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349 Craiova, Romania; [email protected]
14 Department of Gastroenterology, Research Center of Gastroenterology and Hepatology, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349 Craiova, Romania; [email protected]
; Scorei Ion Romulus 2
; Soriano-Ursúa, Marvin A 3
; Mogoşanu, George Dan 1
; Belu Ionela 4 ; Ciocîlteu Maria Viorica 5 ; Biţă, Cristina Elena 6 ; Rău Gabriela 7 ; Pisoschi, Cătălina Gabriela 8 ; Maria-Victoria, Racu 9
; Pinzaru Iurie 9 ; Contreras-Ramos, Alejandra 10
; Kostici Roxana 11 ; Neamţu Johny 12 ; Biciuşcă Viorel 13
; Gheonea, Dan Ionuţ 14 1 Drug Research Center, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349 Craiova, Romania; [email protected] (A.B.); [email protected] (G.D.M.); [email protected] (M.V.C.); [email protected] (G.R.); [email protected] (C.G.P.); [email protected] (R.K.); [email protected] (J.N.), Department of Pharmacognosy & Phytotherapy, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349 Craiova, Romania
2 Department of Biochemistry, BioBoron Research Institute, S.C. Natural Research S.R.L., 31B Dunării Street, 207465 Podari, Romania; [email protected]
3 Department of Physiology, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Diaz Mirón, Mexico City 11340, Mexico; [email protected]
4 Drug Research Center, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349 Craiova, Romania; [email protected] (A.B.); [email protected] (G.D.M.); [email protected] (M.V.C.); [email protected] (G.R.); [email protected] (C.G.P.); [email protected] (R.K.); [email protected] (J.N.), Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349 Craiova, Romania
5 Drug Research Center, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349 Craiova, Romania; [email protected] (A.B.); [email protected] (G.D.M.); [email protected] (M.V.C.); [email protected] (G.R.); [email protected] (C.G.P.); [email protected] (R.K.); [email protected] (J.N.), Department of Instrumental and Analytical Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349 Craiova, Romania
6 Department of Rheumatology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349 Craiova, Romania; [email protected]
7 Drug Research Center, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349 Craiova, Romania; [email protected] (A.B.); [email protected] (G.D.M.); [email protected] (M.V.C.); [email protected] (G.R.); [email protected] (C.G.P.); [email protected] (R.K.); [email protected] (J.N.), Department of Organic Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349 Craiova, Romania
8 Drug Research Center, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349 Craiova, Romania; [email protected] (A.B.); [email protected] (G.D.M.); [email protected] (M.V.C.); [email protected] (G.R.); [email protected] (C.G.P.); [email protected] (R.K.); [email protected] (J.N.), Department of Biochemistry, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349 Craiova, Romania
9 National Agency for Public Health, 67A Georghe Asachi Street, MD-2028 Chisinau, Moldova; [email protected] (M.-V.R.); [email protected] (I.P.)
10 Laboratory of Molecular Biology in the Congenital Malformations Unit, Children’s Hospital of Mexico Federico Gomez (HIMFG), Calle Dr. Marques 162, Col. Doctores, Alc. Cuahutémoc, Mexico City 06720, Mexico; [email protected]
11 Drug Research Center, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349 Craiova, Romania; [email protected] (A.B.); [email protected] (G.D.M.); [email protected] (M.V.C.); [email protected] (G.R.); [email protected] (C.G.P.); [email protected] (R.K.); [email protected] (J.N.), Department of Toxicology, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349 Craiova, Romania
12 Drug Research Center, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349 Craiova, Romania; [email protected] (A.B.); [email protected] (G.D.M.); [email protected] (M.V.C.); [email protected] (G.R.); [email protected] (C.G.P.); [email protected] (R.K.); [email protected] (J.N.), Department of Physics, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349 Craiova, Romania
13 Department of Internal Medicine–Pneumology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349 Craiova, Romania; [email protected]
14 Department of Gastroenterology, Research Center of Gastroenterology and Hepatology, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349 Craiova, Romania; [email protected]
Pharmaceuticals; Basel
Volume
18
Issue
6
First page
766
Number of pages
29
Publication year
2025
Publication date
2025
Place of publication
Basel
Country of publication
Switzerland
Publication subject
e-ISSN
14248247
Source type
Scholarly Journal
Language of publication
English
Document type
Review
Publication history
Online publication date
2025-05-22
Milestone dates
2025-04-15 (Received); 2025-05-21 (Accepted)
Publication history
First posting date
22 May 2025
ProQuest document ID
3223931358
Document URL
https://www.proquest.com/scholarly-journals/microbiota-accessible-borates-as-novel-emerging/docview/3223931358/se-2?accountid=208611
Copyright
© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Last updated
2025-06-25
Database
ProQuest One Academic