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The largest migratory flow in the Americas is south-north, with the US as the primary destination. The main intraregional migratory routes extend from South America through Panama and Central America to Mexico, with the Darién Gap being the most dangerous route. Challenges in the Darién Gap include harsh natural conditions and security risks from criminal groups. Human smuggling has become profitable, with migrants enduring perilous journeys. International protection along these routes is mixed, encompassing both voluntary and forced migration. Regional governments struggle to establish cooperation due to politicization of migration policies and US influence. The CAR+40 Process failed to address dangerous journeys effectively, leaving civil society organizations to fill the gaps. Recommendations for a comprehensive regional response were not incorporated into the final CAR+40 documents, representing a missed opportunity to enhance migrant protection and regional stability.