Abstract
Long-term exposure to nonstandard work schedules can result in circadian misalignment, which has been linked to a series of maladies. To test whether modulating light patterns reduces shiftwork-induced rest/activity disruptions, 30 male C57BL/6 J mice individually housed in cages outfitted with running wheels were exposed to 6 simulated shiftwork light interventions. Mice experiencing high light levels during shiftwork exhibited a significant decrease in activity compared to low light levels during shiftwork and a conventional 12 L:12D condition, indicating circadian misalignment. In contrast, mice experiencing shiftwork in darkness combined with either modulated evening light pulses or circadian blind, vision-permissive light showed similar levels of rest/activity compared to a 12 L:12D condition, with phasor analysis indicating that their 24-h circadian rest/activity patterns were not misaligned. The results show that exposure to light that permits visibility but is below activation of the circadian system during shiftwork can prevent circadian misalignment.
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1 University of Pittsburgh, Division of Endocrinology and Metabolism, Diabetes and Beta Cell Biology Center, Department of Medicine, Pittsburgh, USA (GRID:grid.21925.3d) (ISNI:0000 0004 1936 9000)
2 Icahn School of Medicine at Mount Sinai, Light and Health Research Center, Department of Population Health Science and Policy, New York, USA (GRID:grid.59734.3c) (ISNI:0000 0001 0670 2351)
3 Albany Medical College, Department of Molecular and Cellular Physiology, Albany, USA (GRID:grid.413558.e) (ISNI:0000 0001 0427 8745)
4 University of Pittsburgh, Division of Cardiology, Department of Pediatrics, Children’s Hospital of Pittsburgh, Pittsburgh, USA (GRID:grid.21925.3d) (ISNI:0000 0004 1936 9000)
5 Beckman Research Institute of City of Hope, Department of Diabetes Complications & Metabolism, Duarte, USA (GRID:grid.21925.3d) (ISNI:0000 0004 0389 7968)