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The blockchain trilemma—balancing decentralization, security, and scalability—remains a critical challenge in distributed ledger technology. Despite significant advancements, achieving all three attributes simultaneously continues to elude most blockchain systems, often forcing trade-offs that limit their real-world applicability. This review paper synthesizes current research efforts aimed at resolving the trilemma, focusing on innovative consensus mechanisms, sharding techniques, layer-2 protocols, and hybrid architectural models. We critically analyze recent breakthroughs, including Directed Acyclic Graph (DAG)-based structures, cross-chain interoperability frameworks, and zero-knowledge proof (ZKP) enhancements, which aim to reconcile scalability with robust security and decentralization. Furthermore, we evaluate the trade-offs inherent in these approaches, highlighting their practical implications for enterprise adoption, decentralized finance (DeFi), and Web3 ecosystems. By mapping the evolving landscape of solutions, this review identifies gaps in current methodologies and proposes future research directions, such as adaptive consensus algorithms and artificial intelligence-driven (AI-driven) governance models. Our analysis underscores that while no universal solution exists, interdisciplinary innovations are progressively narrowing the trilemma’s constraints, paving the way for next-generation blockchain infrastructures.