Content area

Abstract

Mass spectrometry (MS) analysis plays a crucial role in the biomedical field; however, the high dimensionality and complexity of MS data pose significant challenges for feature extraction and classification. Deep learning has become a dominant approach in data analysis, and while some deep learning methods have achieved progress in MS classification, their feature representation capabilities remain limited. Most existing methods rely on single-channel representations, which struggle to effectively capture structural information within MS data. To address these limitations, we propose a Multi-Channel Embedding Representation Module (MSMCE), which focuses on modeling inter-channel dependencies to generate multi-channel representations of raw MS data. Additionally, we implement a feature fusion mechanism by concatenating the initial encoded representation with the multi-channel embeddings along the channel dimension, significantly enhancing the classification performance of subsequent models. Experimental results on four public datasets demonstrate that the proposed MSMCE module not only achieves substantial improvements in classification performance but also enhances computational efficiency and training stability, highlighting its effectiveness in raw MS data classification and its potential for robust application across diverse datasets.

Details

1009240
Business indexing term
Title
MSMCE: A novel representation module for classification of raw mass spectrometry data
Publication title
PLoS One; San Francisco
Volume
20
Issue
8
First page
e0321239
Number of pages
21
Publication year
2025
Publication date
Aug 2025
Section
Research Article
Publisher
Public Library of Science
Place of publication
San Francisco
Country of publication
United States
e-ISSN
19326203
Source type
Scholarly Journal
Language of publication
English
Document type
Journal Article
Publication history
 
 
Milestone dates
2025-03-03 (Received); 2025-07-16 (Accepted); 2025-08-06 (Published)
ProQuest document ID
3237430616
Document URL
https://www.proquest.com/scholarly-journals/msmce-novel-representation-module-classification/docview/3237430616/se-2?accountid=208611
Copyright
© 2025 Zhang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Last updated
2025-08-07
Database
ProQuest One Academic