HBV母婴零传播——从争议到共识

Abstract

母婴传播是HBV最主要的传播途径，预防HBV母婴传播是乙型肝炎防控的关键环节，也是2030年全球消除乙型肝炎的五大核心战略支柱之一。新生儿联合免疫和妊娠期的抗病毒干预是阻断母婴传播的关键措施，实施新生儿联合免疫和妊娠期抗病毒干预的综合策略能够加速实现消除母婴传播的目标。我国学者提出“乙型肝炎母婴零传播”的理念，并在全国范围开展了“乙肝母婴零传播工程” (“小贝壳”项目) ，旨在推动母婴阻断策略的实施，为我国消除病毒性肝炎打好基础。“小贝壳”项目为阻断乙型肝炎母婴传播提供了详细的实施策略、成功的实践经验及可靠的数据支持，凝聚了学术界对“乙型肝炎母婴零传播”的共识，对我国以及全球实现消除HBV母婴传播具有重要的参考价值。

Alternate abstract:

Mother-to-child transmission is the major route of transmission for hepatitis B virus (HBV), and prevention of the mother-to-child transmission of HBV is the key link in the prevention and control of hepatitis B and one of the five essential core strategies for achieving the global elimination of hepatitis B by 2030. Combined immunization for neonates born to HBV-infected mothers and maternal antiviral intervention during pregnancy are important measures for blocking mother-to-child transmission, and thereby, the implementation of the comprehensive strategy of combined immunization and maternal antiviral intervention will help to accelerate the process of eliminating mother-to-child transmission. Chinese scholars have put forward the concept of “zero mother-to-child transmission of hepatitis B” and launched “Shield Program” in China, aiming to promote the implementation of the preventive strategy for mother-to-child transmission and lay a solid foundation for eliminating viral hepatitis in China. The Shield Program has provided detailed implementation strategies, successful practice experience, and reliable data for blocking the mother-to-child transmission of hepatitis B, fostering the consensus on the zero mother-to-child transmission of HBV in the academic community, and it also has an important reference value for eliminating the mother-to-child transmission of HBV in China and globally.