Abstract

肝巨噬细胞是肝脏中重要的免疫细胞,其通过极化为M1型和M2型,分别表达“促炎因子”和“抑炎因子”,进而发挥调控炎症损伤反应的作用。肝祖细胞恶变是肝癌癌前病变恶性进展的核心机制,其发生的关键因素是炎症损伤微环境的持续刺激,与M1/M2巨噬细胞极化密切相关。本综述主要围绕“巨噬细胞极化-慢性炎症-肝祖细胞恶变”关系进行探讨,为肝癌癌前病变的预防和治疗提供重要的理论依据。

Alternate abstract:

Liver macrophages are important immune cells in the liver, and they express proinflammatory factors and anti-inflammatory factors through polarization into M1 type and M2 type, respectively, thereby playing a role in regulating inflammatory damage response. The malignant transformation of hepatic progenitor cells is the core mechanism of the malignant progression of hepatic precancerous lesions, and its key factor is the continuous stimulation of inflammatory microenvironment, which is closely associated with M1/M2 macrophage polarization. This review mainly focuses on the association between macrophage polarization, chronic inflammation, and malignant transformation of hepatic progenitor cells, so as to provide a theoretical basis for the prevention and treatment of hepatic precancerous lesions.

Details

Title
肝巨噬细胞调控肝癌癌前病变恶变的研究进展
Author
闫瑞娟; 焦俊喆; 黄玉; 闫曙光; 魏海梁; 常占杰; 郭英君  VIAFID ORCID Logo  ; 李京涛  VIAFID ORCID Logo 
Pages
1039-1043
Section
Review
Publication year
2024
Publication date
2024
Publisher
Journal of Clinical Hepatology
ISSN
10015256
e-ISSN
20973497
Source type
Scholarly Journal
Language of publication
Chinese
ProQuest document ID
3238691645
Copyright
© 2024. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.