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Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide and is closely associated with obesity, insulin resistance, and other metabolic diseases. There are currently no drugs approved for treatment, and routine lifestyle management can hardly have a positive impact on this disease. This article reviews the investigational new drugs for NAFLD, including metabolic regulators, anti-inflammatory antioxidants, and anti-fibrosis agents, and summarizes the results of their clinical studies, so as to provide new ideas for the clinical treatment of NAFLD and the and development of related drugs.
