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Cognitive deficits have a high impact on quality of life in Parkinson’s disease (PD). This study takes into account the multifaceted etiology of cognition to estimate the cognitive outcome after deep brain stimulation (DBS) surgery in PD. Clinical, neuropsychological, perioperative, neuroimaging- and laboratory-based risk factors for cognitive dysfunction were prospectively assessed prior to surgery in 57 patients (21 female; age 60.2 ± 8.2; disease duration 10.5 ± 5.9 years, preregistered 9 June 2019 at clinicaltrials.gov, NCT03982953). Elastic net regularized regression and leave-one-out cross-validation were used to fit a multivariable model with the Montréal Cognitive Assessment (MoCA) change one year after surgery as primary outcome. The backward span had the most robust association with the cognitive outcome (rho = 0.499, p < 0.001**; c = 0.302). We propose a post-hoc prediction model for cognition based on the baseline MoCA and backward span (R² = 0.50). After clinical validation, our short and easily applicable prediction model could improve informed therapeutic decision making.
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1 Movement Disorder and Neuromodulation Unit, Department of Neurology and Experimental Neurology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu, Berlin, Germany (ROR: https://ror.org/001w7jn25) (GRID: grid.6363.0) (ISNI: 0000 0001 2218 4662)
2 Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin, Berlin, Germany (ROR: https://ror.org/001w7jn25) (GRID: grid.6363.0) (ISNI: 0000 0001 2218 4662); Robert Koch-Institute, Centre for Artificial Intelligence in Public Health Research, Berlin, Germany (ROR: https://ror.org/01k5qnb77) (GRID: grid.13652.33) (ISNI: 0000 0001 0940 3744)
3 Department of Neurosurgery, Charité - Universitätsmedizin, Berlin, Germany (ROR: https://ror.org/001w7jn25) (GRID: grid.6363.0) (ISNI: 0000 0001 2218 4662)
4 Department of Neurosurgery, University Hospital Düsseldorf, Düsseldorf, Germany (ROR: https://ror.org/006k2kk72) (GRID: grid.14778.3d) (ISNI: 0000 0000 8922 7789)
5 Movement Disorder and Neuromodulation Unit, Department of Neurology and Experimental Neurology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu, Berlin, Germany (ROR: https://ror.org/001w7jn25) (GRID: grid.6363.0) (ISNI: 0000 0001 2218 4662); Berlin Institute of Health at Charité - Universitätsmedizin, Berlin, Germany (ROR: https://ror.org/0493xsw21) (GRID: grid.484013.a)
6 Berlin Center for Advanced Neuroimaging (BCAN), Charité - Universitätsmedizin, Berlin, Germany (ROR: https://ror.org/001w7jn25) (GRID: grid.6363.0) (ISNI: 0000 0001 2218 4662); Technische Universität, Berlin, Germany (ROR: https://ror.org/03v4gjf40) (GRID: grid.6734.6) (ISNI: 0000 0001 2292 8254); Physikalisch-Technische Bundesanstalt, Berlin, Germany (ROR: https://ror.org/05r3f7h03) (GRID: grid.4764.1) (ISNI: 0000 0001 2186 1887)
7 Berlin Center for Advanced Neuroimaging (BCAN), Charité - Universitätsmedizin, Berlin, Germany (ROR: https://ror.org/001w7jn25) (GRID: grid.6363.0) (ISNI: 0000 0001 2218 4662)
8 Department of Anesthesiology and Intensive Care Medicine, Campus Charité Mitte and Campus Virchow-Klinikum, Charité - Universitätsmedizin, Berlin, Germany (ROR: https://ror.org/001w7jn25) (GRID: grid.6363.0) (ISNI: 0000 0001 2218 4662)
9 Movement Disorder and Neuromodulation Unit, Department of Neurology and Experimental Neurology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu, Berlin, Germany (ROR: https://ror.org/001w7jn25) (GRID: grid.6363.0) (ISNI: 0000 0001 2218 4662); Berlin School of Mind and Brain, Humboldt-Universität zu, Berlin, Germany (ROR: https://ror.org/01hcx6992) (GRID: grid.7468.d) (ISNI: 0000 0001 2248 7639); Deutsches Zentrum für Neurodegenerative Erkrankungen, Berlin, Germany (ROR: https://ror.org/043j0f473) (GRID: grid.424247.3) (ISNI: 0000 0004 0438 0426)