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Cancer cachexia is a multifactorial metabolic syndrome characterized by an accelerated involuntary loss of body weight and depletion of skeletal muscle mass. This condition is associated with muscle degradation, impaired immune function, reduced functional capacity, compromised quality of life, and diminished survival in cancer patients. Systemic cancer-induced inflammation, alongside localized muscle inflammation, drives cachexia progression by disrupting the balance between muscle protein synthesis and degradation, favoring catabolism. The aim of this study was to determine the efficacy of an 8 wk low-tension, high-tension, and combined-tension exercise interventions in combating cancer cachexia as a possible therapeutic intervention. A total of 60 mice (50 ApcMin/+ mice and 10 C57BL/6 wild-type mice) were used in this study. After completing baseline physical function assessments, (grip strength, fatigue resistance, and sensorimotor coordination) 10 ApcMin/+ mice were sacrificed for tissue sample collection. The remaining ApcMin/+ mice were randomly assigned into either a sedentary control group (SC-APC, n=10) or one of three EC intervention groups (n=10/group) : 1) low-tension exercise group (L-APC), 2) high-tension exercise group (H-APC), and 3) combination of low- and high-tension exercise group (LH-APC). Additionally, a non-tumor-bearing wild-type group (WT) (n=10) served as a control group. The results of the study were; All exercise groups exhibited lower total body weight loss compared to the SC-APC mice; 2) The gastrocnemius tissue weight was higher in all exercise groups compared to the SC-APC mice, 3) Exercise provided some protection of the spleen and liver tissue weights (L-APC liver tissue weight was significantly lower than the SC-APC group (-17.2%, p < 0.001) and the H-APC group (-11.0%, p = 0.016), while the LH-APC liver tissue weight was significantly lower than the SC-APC group liver weight (-13.4%, p < 0.001)) suggesting a reduction of splenomegaly and hepatomegaly, 4) Post-intervention physical function performance was relatively maintained in all exercise groups. Grip strength - The SC-APC and L-APC groups displayed significantly lower grip strength from their baseline (SC-APC:-27.4%, p < 0.001, and L-APC:-8.9%, p < 0.001)). Wire hang time - The SC-APC group exhibited a significant decline in hang time from pre- to post-intervention (- 42.1%, p < 0.001), while the H-APC group showed a non-significant trend toward decreased performance (-8.9%, p = 0.095). Sensorimotor coordination - There were no significant differences between pre-intervention and post-intervention sensorimotor coordination for the L-APC, H-APC, and LH-APC groups. 5) The combined exercise group displayed lower gene expression values that trended towards significance for TNF-α (+59.2%, p = 0.066), and significantly lower gene expression values for Atrogin-1 (-58%, p = 0.021). 6) Lastly, the H-APC mice presented higher IL-1β than the WT mice (+99.7, p = 0.090). This study concludes that the responses to exercise demonstrated positive trends that supports the use of both exercise interventions that favors the combined-tension exercise in combating cancer cachexia, while the high-tension exercise intervention yielded mixed results in addressing cancer cachexia.