The Effects of a Novel Nutraceutical Composition Containing Coenzyme Q10, Resveratrol, Extracts of Ginkgo biloba Leaf, Garlic Bulb, Red Yeast Rice, and Bovine Colostrum on Cardiac Dysfunction

Abstract

ABSTRACT

With heart disease being the leading cause of death worldwide, cost‐effective therapies supporting healthy cardiac function are highly needed. Oxidative stress and hypercholesterolemia are risk factors in the pathogenesis of cardiac dysfunction. Many nutraceutical compositions containing Coenzyme Q₁₀, resveratrol, extracts of Ginkgo biloba leaf, Garlic Bulb, red rice yeast, and bovine colostrum appear to have the potential to improve cardiac function. In the present study, we aimed to evaluate whether a new combination containing the abovementioned nutraceuticals (Cardio) is protective against damage to cardiac function. In this study, C57BL/6J mice were divided into groups of control, high‐fat‐cholesterol diet fed (HFHC), and HFHC diet + Cardio (Cardio group), and fed for 16 weeks. Parameters of plasma lipid levels, inflammation, oxidative damage, and cardiac function were measured. Cardio treatment significantly inhibited hypercholesterolemia, reduced levels of cardiac damage markers including LDH and CK, improved cardiac function, and reduced HFHC diet‐induced increased levels of inflammatory cytokines including TNF‐α and IL‐1β. Our data showed that Cardio has a protective effect on cardiac dysfunction probably by ameliorating hypercholesterolemia, inflammation, and oxidative stress.