Content area

Abstract

Lung cancer continues to be one of the most widespread and deadly cancer diagnoses that affects humans worldwide. Early detection of lung cancer leads to decreased mortality rates; however, several challenges hinder the development and deployment of effective predictive models. These challenges consist of mainly the problem of high computational power to evaluate large-scale medical data, privacy and security of medical data, limited data sharing between medical organizations and interpretability to handle the black box problem that AI-based models face. Such limitations have posed severe difficulties to the utilization of conventional approaches in the prediction of lung cancer, thus limiting them most importantly for general use, especially in clinical practice settings in real time. To address these challenges, this research introduced a novel lung cancer prediction model that utilizes an integrated framework combining MapReduce, Private Blockchain, Federated Learning (FL), and Explainable Artificial Intelligence (XAI). It improves lung cancer detection using MapReduce to handle large lung cancer datasets, supporting rapid and scalable learning. Private Blockchain is used for the secure, tamper-proof, and immutable processing of patient information, whereas FL allows healthcare sectors to train models together, without compromising patients’ privacy. Moreover, it also employed XAI to improve the model’s interpretability so clinicians can understand and rely on AI predictions. Together, these methods improve AI’s efficiency and trustworthiness in medical applications. This proposed model provides better and more secure lung cancer predictions, ensuring interpretability and collaboration. With an exceptional accuracy of 98.21% and a miss rate of just 1.79%, it outperforms previously published approaches, establishing a new benchmark for privacy-preserving, explainable, and scalable AI models in healthcare.

Details

1009240
Business indexing term
Title
Secure and interpretable lung cancer prediction model using mapreduce private blockchain federated learning and XAI
Author
Adnan, Khan Muhammad 1 ; Ghazal, Taher M. 2 ; Saleem, Muhammad 3 ; Farooq, Muhammad Sajid 4 ; Yeun, Chan Yeob 5 ; Ahmad, Munir 6 ; Lee, Sang-Woong 1 

 Pattern Recognition and Machine Learning Lab, Faculty of Artificial Intelligence and Software, Gachon University, 13557, Seongnam-si, Republic of Korea (ROR: https://ror.org/03ryywt80) (GRID: grid.256155.0) (ISNI: 0000 0004 0647 2973) 
 Department of Networks and Cybersecurity, Hourani Center for Applied Scientific Research, Al-Ahliyya Amman University, Amman, Jordan (ROR: https://ror.org/00xddhq60) (GRID: grid.116345.4) (ISNI: 0000 0004 0644 1915) 
 Chitkara University Institute of Engineering and Technology, Chitkara University, 140401, Rajpura, Punjab, India (ROR: https://ror.org/057d6z539) (GRID: grid.428245.d) (ISNI: 0000 0004 1765 3753) 
 Department of Cyber Security, NASTP Institute of Information Technology, 58810, Lahore, Pakistan 
 Centre for Secure Cyber-Physical Systems (C2PS), Computer Science Department, Khalifa University, Abu Dhabi, United Arab Emirates (ROR: https://ror.org/05hffr360) (GRID: grid.440568.b) (ISNI: 0000 0004 1762 9729) 
 University College, Korea University, 02841, Seoul, Republic of Korea (ROR: https://ror.org/047dqcg40) (GRID: grid.222754.4) (ISNI: 0000 0001 0840 2678) 
Volume
15
Issue
1
Pages
35693
Number of pages
21
Publication year
2025
Publication date
2025
Section
Article
Publisher
Nature Publishing Group
Place of publication
London
Country of publication
United States
Publication subject
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
Document type
Journal Article
Publication history
 
 
Online publication date
2025-10-13
Milestone dates
2025-09-09 (Registration); 2025-02-05 (Received); 2025-09-09 (Accepted)
Publication history
 
 
   First posting date
13 Oct 2025
ProQuest document ID
3260575996
Document URL
https://www.proquest.com/scholarly-journals/secure-interpretable-lung-cancer-prediction-model/docview/3260575996/se-2?accountid=208611
Copyright
© The Author(s) 2025. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Last updated
2025-12-10
Database
ProQuest One Academic