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Dimazon is known to stimulate the proliferation of epithelial cells. The dimazon released from locally attached polymer foils could be efficient for the treatment of skin damage. So, knowledge on the characteristics of the dimazon released from polymer matrices is important in establishing the continuous and predictable delivery of drug to a target. The spectrum of dimazon released from PVA foils is analysed based on the empirical Korsmeyer–Peppas model. The influence of the drug’s concentration and the film’s anisotropy, induced by stretching, on the delivery mechanism is highlighted. The results of this study could help clinical researchers establish a protocol for using dimazon from PVA foils in skin therapy.

Details

1009240
Subject
Polymers;
Toxicity;
Diuretics;
Experiments;
Epithelium;
Ulcers;
Calibration;
Solvents;
Edema;
Anisotropy;
Medical equipment;
Molecular weight;
Foils;
Drug dosages;
Ethanol
Identifier / keyword
stretched and unstretched PVA films containing dimazon; electronic absorption spectrum of dimazon; dimazon release kinetics; Korsmeyer–Peppas model
Title
Korsmeyer–Peppas Model for Diacetylaminoazotoluene (Dimazon) Release from PVA Foils: A Spectral Study
Author
Gasner, Paul 1   VIAFID ORCID Logo  ; Babusca Daniela 2   VIAFID ORCID Logo  ; Vleoanga Andrei 3 ; Dorohoi, Dana Ortansa 1   VIAFID ORCID Logo 

1  Faculty of Physics, Alexandru Iona Cuza University, 11 Carol I Blvd., 700506 Iași, Romania; [email protected] 
2  Department of Physics, Al. Vlahuta School, 10 Buridava Street, 700432 Iași, Romania; [email protected] 
3  Faculty of General Medicine, Gr. T. Popa University of Medicine and Pharmacy, 16 Universității Street, 700115 Iași, Romania; [email protected] 
Publication title
Symmetry; Basel
Volume
17
Issue
10
First page
1739
Number of pages
15
Publication year
2025
Publication date
2025
Publisher
MDPI AG
Place of publication
Basel
Country of publication
Switzerland
Publication subject
Sciences: Comprehensive Works
e-ISSN
20738994
Source type
Scholarly Journal
Language of publication
English
Document type
Journal Article
Publication history
 
 
Online publication date
2025-10-15
Milestone dates
2025-08-18 (Received); 2025-10-03 (Accepted)
Publication history
 
 
   First posting date
15 Oct 2025
DOI
https://doi.org/10.3390/sym17101739
ProQuest document ID
3265951857
Document URL
https://www.proquest.com/scholarly-journals/korsmeyer-peppas-model-diacetylaminoazotoluene/docview/3265951857/se-2?accountid=208611
Copyright
© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Last updated
2025-10-28
Database
ProQuest One Academic