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[...]MASLD poses an increased risk of cardiovascular comorbidities, with cardiovascular complications being the primary cause of death in patients with MASLD. SGLT2 inhibitors may activate fasting-mimicking pathways, which, in turn, promote the release of mediators (such as FGF-21 and ketone bodies, among others) with positive metabolic effects. [...]they seem to stimulate the activation of lipolysis, particularly in ectopic fat, thereby reducing the burden of lipotoxicity in targeted tissues [5]. Declarations Conflict of interest There are no conflicts of interest related to this article.

Details

Subject
Antidiabetics;
Diabetes mellitus (non-insulin dependent);
Diabetes;
Kidney diseases;
Fatty liver;
Cardiovascular diseases;
Metabolism;
Conflicts of interest;
Steatosis;
Liver diseases;
Lipolysis;
Ketones;
Comorbidity
Business indexing term
Title
The effect of SGLT2 inhibitors on hepatic steatosis detected by MRI-PDFF in patients with type 2 Diabetes mellitus and metabolic-associated steatotic liver disease: comment
Author
Di Vincenzo, Angelo 1   VIAFID ORCID Logo  ; Capone, Federico 1 ; Rossato, Marco 1 

1  University Hospital of Padova, Department of Medicine, Internal Medicine III Unit and Center for the Study and the Integrated Treatment of Obesity, Padua, Italy (GRID:grid.411474.3) (ISNI:0000 0004 1760 2630) 
Publication title
Internal and Emergency Medicine; Milan
Volume
20
Issue
8
Pages
2613-2614
Publication year
2025
Publication date
Nov 2025
Publisher
Springer Nature B.V.
Place of publication
Milan
Country of publication
Netherlands
Publication subject
Medical Sciences--Internal Medicine
ISSN
18280447
e-ISSN
19709366
Source type
Scholarly Journal
Language of publication
English
Document type
Letter
Publication history
 
 
Online publication date
2025-06-17
Milestone dates
2025-06-12 (Registration); 2025-06-10 (Received); 2025-06-11 (Accepted)
Publication history
 
 
   First posting date
17 Jun 2025
DOI
https://doi.org/10.1007/s11739-025-04024-z
ProQuest document ID
3278665981
Document URL
https://www.proquest.com/scholarly-journals/effect-sglt2-inhibitors-on-hepatic-steatosis/docview/3278665981/se-2?accountid=208611
Copyright
© The Author(s), under exclusive licence to Società Italiana di Medicina Interna (SIMI) 2025.
Last updated
2025-12-03
Database
2 databases
  • ProQuest One Academic
  • ProQuest One Academic