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Hemophilia is an X-linked recessive disorder divided into two different subtypes, hemophilia A (HA) and hemophilia B (HB), which result in a deficiency or complete absence of clotting factors VIII and IX. The current standard of care is prophylactic lifelong intravenous self-infusions of clotting factors (factor concentrates) two to three times per week. Depression, anxiety, and uncontrolled pain are associated with reduced adherence to treatment in people living with hemophilia. The purpose of this study was to examine if a mindfulness intervention impact anxiety prior to self-administered intravenous infusion of weekly factor concentrates in adults living with HA and HB. This was an eight-week repeated measures quantitative study conducted utilizing a purposive sample of adults living with HA and HB in the US. A three to five-minute breathing meditation from an online website or mobile device was used for the mindfulness intervention. Community educators throughout the US were asked to assist in recruiting prospective participants. Participants anxiety levels were measured with the State Trait Anxiety Inventory – state anxiety scale-6 (STAI-6) at three points over the four-week intervention period. The participants (n= 24) completed the pre STAI-6 survey and the post survey in week one (n=24) and completed the post-post survey in week four (n=17). The results indicated a significant decrease in participants’ self-reported anxiety during the first week following the mindfulness intervention and prior to self-infusion (F(1,15) = 18.87, p < .001). The effect was maintained through the fourth week of the intervention since there was no significant change from the week one post-intervention anxiety score to week four post-post intervention anxiety score (F(1,15) = 1.31, p < .27). While anxiety levels were not high in this sample of adults with HA or HB, the results of the study indicated a mindfulness intervention reduced anxiety levels prior to the self-infusion of weekly intravenous factor concentrates. Ongoing research into the usefulness of mindfulness interventions for adults living with HA and HB could be beneficial in promoting support for the life-long self-care burden of self-infused intravenous factor concentrates.