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Diagnosis and treatment of trauma and stress related disorders is challenged by the diverse findings in published research literature and health governing bodies’ clinical practice guidelines, which endorses differing frontline recommended evidence-based treatments. A systematic literature review was utilized that globally examined research articles to analyze neurofeedback as an effective treatment modality for alleviating PTSD symptomology and loss of diagnosis. As a result, the updated Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) 2020 was the instrument used to compile this study's collected data. This tool was designed primarily to help review research projects assessing the harms and benefits of healthcare interventions. The targeted populations reviewed in the articles were adults diagnosed with PTSD and mental health providers who treated the disorder. Results found that neurofeedback shows similar effect sizes in the merging evidence categories when compared to other frontline recommended PTSD treatments. Furthermore, the findings of this study revealed neurofeedback has a more significant, longer lasting effect than psychological therapies and pharmacological treatments. The implications of this study include extending the theory of neurofeedback as an effective evidenced-based frontline treatment for PTSD and its associated comorbidities for updated clinical practice guidelines and policy implications.