Content area
Abstract
ABSTRACT
Aims
We aimed to investigate the behavioral aftereffects of a novel noninvasive brain stimulation technique—transcranial pulse stimulation (TPS)—applied over the right motor cortex (rM1) in healthy adults.
Methods
Thirty‐four healthy adults underwent a randomized, subject‐ and analyst‐ blind, crossover trial, receiving active TPS over the rM1 or control TPS over the vertex in two sessions 24 h apart. Motor performance was assessed using the Nine‐Hole Peg Test (NHPT) and the Simple Reaction Time Task (SRTT) before, immediately after, and every 10 min for 40 min after each session. A linear mixed model and post hoc analyses were applied to evaluate the effects.
Results
No significant interaction effect (stimulation condition × time) was found. The left‐hand NHPT performance significantly improved from 10 min post‐TPS onward in both conditions (
Conclusion
A single session of rM1‐TPS does not yield significant improvements in motor dexterity compared to vertex‐TPS. Future well‐powered studies with a sham control condition and multiple stimulation sessions are needed to investigate the aftereffects using a combination of neurophysiological and neuroimaging approaches.
Trial Registration
This study was registered in ClinicalTrial.gov in April 2024 (NCT06312930)
Details
; Chak, Ivan Kin‐Yeung 1 ; Kan, Rebecca Lai‐Di 1 ; Jin, Min‐Xia 2 ; Zhang, Bella Bing‐Bing 1 ; Xia, Adam Wei‐Li 1 ; Lin, Tim Tian‐Ze 1 ; Wang, Sharie Xiao 1 ; Liu, Jian‐Hui 3 ; Cheung, Teris 4 ; Kranz, Georg S. 5
1 Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong, China
2 Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong, China, Shanghai YangZhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, China
3 Department of Anesthesiology, School of Medicine, Tongji University, Shanghai, China
4 School of Nursing, The Hong Kong Polytechnic University, Hong Kong, China
5 Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong, China, Mental Health Research Center (MHRC), The Hong Kong Polytechnic University, Hong Kong, China, University Research Facility in Behavioral and Systems Neuroscience (UBSN), The Hong Kong Polytechnic University, Hong Kong, China