Estudio del efecto de darbepoetina alpha en isquemia-reperfusión renal: Su uso como agente protector y reparador del daño renal isquémico.

Abstract

Ischemia is one of the most frequent causes of Acute Renal Failure (ARP). Ischemic injury during kidney transplant delays graft function and viability.

Renal ischemic injury mainly affects proximal tubule epithelial cells, especially those located in the S3 segment of the nephron. These cells are very sensitive to lack of oxygen and nutrients, and their damage is characterised by intercellular union disruption, loss of adhesion to basal membrane, tubule epithelial denudation, disruption of tubule basal membrane and interstitial edema.