Lorazepam/passiflora/valerian root interaction: First report of interactions between passiflora and lorazepam, and valerian root and lorazepam, leading to movement disorders and drowsiness: case report

A 40-year-old man developed movement disorders and drowsiness following self-medication with valerian root and passiflora [dosages not clearly stated], and while receiving lorazepam. His symptoms were attributed to an interaction between the herbal medicines and lorazepam.

The man had a history of generalised anxiety disorder and dream disorders, and had been receiving lorazepam 2mg/24h for 2 months. He ingested an infusion of valerian root about 2 hours before bedtime for 2 consecutive days, and also took a mixture of the same infusion with an unlimited quantity of dry passiflora herbs before going to bed. He experienced no side effects, and the infusion dosage...