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A 60-year-old woman with a history of hypertension and ischaemic stroke developed upper digestive haemorrhage secondary to a duodenal ulcer during treatment with etoricoxib for back pain and aspirin.
The woman, who had been receiving aspirin 100 mg/day for 2 years and had started receiving etoricoxib 60 mg/day 3 months earlier, presented with a 1-week history of skin and mucosal pallor and a 3-day history of bloody stools. Melaena was evident on rectal examination, and laboratory investigations revealed the following: haemoglobin 6.5 g/dL, MCV 80fL, WBC count 10 200/µL, neutrophils 8100/µL, platelet...