VEGF and ephrin-B2: a bloody duo

Abstract

Ephrin-B2 is required for the formation of blood and lymphatic vessels, but the mechanism has been enigmatic. Two independent studies show that ephrin-B2 controls the internalization and signaling of two types of vascular endothelial growth factor (VEGF) receptors--thereby regulating VEGF-induced angiogenesis in normal and pathological conditions. [PUBLICATION ABSTRACT]