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Abstract
The acute toxicity of terbufos and its major metabolites, tested alone, in binary mixtures or in combination with atrazine were evaluated using neonates of the cladoceran Ceriodaphnia cf dubia. Terbufos, terbufos sulfoxide, and terbufos sulfone tested individually were highly toxic to C. cf dubia, with mean 96-h EC^sub 50^ values of 0.08, 0.36, and 0.19 μg/l, respectively. The addition of atrazine (10 μg/l) significantly increased the toxicity of terbufos. The toxicity of terbufos sulfone was unaffected by atrazine, whereas the results for terbufos sulfoxide were equivocal. Equitoxic mixtures of the metabolites showed additive toxicity to C. cf dubia. The high toxicities of terbufos and its environmentally persistent oxidative metabolites suggest that contamination of aquatic systems with this insecticide mixture and the coapplied herbicide atrazine might pose a greater hazard to some biota than their individual toxicities. [PUBLICATION ABSTRACT]