A twist on admixture mapping

Abstract

In many ways, this challenge is similar to the issues facing the study of less common diseases or disease subtypes, such as estrogen receptor-negative breast cancer or ethnicity-specific response to therapy (for example, asthma in Latino/Hispanic populations)15. Because often we do not fully understand the biological basis of a biomarker before applying it in the clinical venue, it makes sense to proceed cautiously and determine whether genome-wide SNP arrays, or perhaps a well-chosen set of ancestry-informative markers, can serve as a clinical test with greater specificity than self-reported ancestry.