Content area

Abstract

Issue Title: Special issue on Mini-MCR issue and SCS-09 - Second International Symposium on Combinatorial Sciences in Biology, Chemistry, Catalysts and Materials

The Gewald reaction of sulfur, cyanoacetic acid derivatives, and oxo-component (G-3CR) yielding highly substituted 2-aminothiophene derivatives has seen diverse applications in combinatorial and medicinal chemistry. Its products are of great use in pharmaceutical industry mainly as small molecular weight inhibitors. We herein review synthetic scope and variations, usage, and structural biology of Gewald products.[PUBLICATION ABSTRACT]

Details

Title
The Gewald multicomponent reaction
Author
Huang, Yijun; Dömling, Alexander
Pages
3-33
Publication year
2011
Publication date
Feb 2011
Publisher
Springer Nature B.V.
ISSN
13811991
e-ISSN
1573501X
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1007/s11030-010-9229-6
ProQuest document ID
857181158
Copyright
Springer Science+Business Media B.V. 2011