Synthesis, characterization and biological activity studies of octahedral nickel(II) complexes

Abstract

Three nickel(II) complexes, namely [Ni(BH)^sub 3^](H2O)(NO3)(ClO^sub 4^) 1, [Ni(BH)^sub 2^(NO3)^sub 2^] 2 and [Ni(BH)(Tren)](ClO^sub 4^)^sub 2^ 3 (BH = Benzoylhydrazine, Tren = Tris(2-aminoethyl)amine) have been synthesized and characterized by physico-chemical techniques. X-ray crystallographic analysis shows the nickel to be six-coordinated in these complexes. The complexes are efficient catalysts for the dismutation of superoxide in alkaline DMSO-NBT assays. The IC^sub 50^ values are 74,108 and 105 μM for 1, 2 and 3, respectively.[PUBLICATION ABSTRACT]