Content area
Full Text
Qual Life Res (2010) 19:6580 DOI 10.1007/s11136-009-9558-z
Mapping analyses to estimate health utilities basedon responses to the OM8-30 otitis media questionnaire
Helen Dakin Stavros Petrou Mark Haggard
Sarah Benge Ian Williamson
Accepted: 11 November 2009 / Published online: 26 November 2009 Springer Science+Business Media B.V. 2009
AbstractPurpose To investigate the statistical relationship between the OM8-30 health-related quality of life measure for children with otitis media with effusion (OME) and measures of health utility (Health Utilities Index [HUI] Mark 3 and Mark2) and to develop models to estimate HUI3 and HUI2 health utilities from OM8-30 scores.
Methods A placebo-controlled, randomised trial (GNOME) evaluating intranasal mometasone in 217 children with OME provided concurrent responses to OM8-30 and HUI at three time points. Ordinary least squares (OLS), generalised linear models and two-step regression analyses were used to predict HUI3 and HUI2 utilities based on OM8-30 facet and domain scores.
Results OLS models including all nine OM8-30 facets with or without predicted hearing level (HL) produced the best predictions of HUI3 utilities (mean absolute error:0.134 with HL and 0.132 without; R2: 0.63 with HL and0.596 without). An OLS model predicting HUI3 utilities based on the two OM8-30 domain scores, reported hearing difculties, predicted HL, age and sex also produced accurate predictions.
Conclusion Regression equations predicting HUI3 and HUI2 utilities based on OM8-30 facet and domain scores have been developed. These provide an empirical basis for estimating quality-adjusted life years (QALYs) for interventions in children with OME.
Keywords Otitis media Glue ear Quality of life
Health state preference value Utility mapping
Cross-walking
AbbreviationsACET Air conduction estimated from tympanometry AIC Akaike information criterionDEV Developmental domain of the OM8-30ENT Ear, nose and throatGLM Generalised linear model(s)
GNOME GPRF [General Practice Research Framework]
Nasal steroids for Otitis Media with Effusion HL Hearing levelHRQoL Health-related quality of lifeHUI Health Utilities IndexMAE Mean absolute errorMAEVal Mean absolute error for the validation dataset
OLS Ordinary least squares [regression] OM8-30 Otitis media questionnaireOME Otitis media with effusion
H. Dakin (&) S. Petrou
Health Economics Research Centre, Department of Public Health, University of Oxford, Old Road Campus, Headington, Oxford OX3 7LF, UKe-mail: [email protected]
S. Petroue-mail: [email protected]
S. PetrouNational Perinatal Epidemiology Unit, University of Oxford, Old Road Campus, Headington, Oxford, UK
M. HaggardMRC Multi-centre Otitis Media Study Group, Department...