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Med Oncol (2009) 26:265268 DOI 10.1007/s12032-008-9112-9
ORIGINAL PAPER
Lung cancer in women: histological type and patient age from 1985 to 2005
Jelena Stojsic Ivan Milovanovic Jelena Radojicic Branislava Milenkovic
Received: 14 May 2008 / Accepted: 14 October 2008 / Published online: 4 November 2008 Humana Press Inc. 2008
Abstract The aim of the study was to analyse changes in histological type and age of presentation in female lung cancer patients during a period of 20 years. The obtained results are compared with those available from the literature published in various parts of the world.
Keywords Lung Cancer Women
Histopathological type Age
Introduction
Lung cancer is the most frequently diagnosed malignant disease throughout the world. In men it is the largest cause of mortality, and in women it is the third largest cause, just after breast and intestinal cancer, but before cervical cancer [13]. Good prevention and early detection of breast and cervical cancer mean that lung cancer will be the leading cause of mortality in women worldwide [4]. In Serbia, lung cancer has a high rate of morbidity and mortality in both sexes [57].
Materials and methods
Pulmonary bioptic tissue specimens sampled from female patients on bronchoscopy and by needle percutaneous biopsy were analysed, as well as tissue samples obtained by
segmental resection, lobectomy and pneumonectomy that were diagnosed with primary lung cancer on routine pathohistological examination. Data was broken down for analysis into 5-year periods from 1985 to 2005. Analysis was based on histological diagnosis in the Department of Pathology of the Institute for Lung Diseases and Tuberculosis at the Clinical Centre of Serbia, the referral institution for lung diseases for Belgrade and Central Serbia.
Lung cancer was classied into three major groups according to the 2004 World Health Organization (WHO) classication: squamous cell type (SCC), small cell lung cancer (SCLC) and adenocarcinoma (AC) [1]. The fourth type comprised other, rare pulmonary malignancies such as adenosquamous cancers, large cell and sarcomatoid lung cancers, carcinoid tumors and salivary gland tumors [1]. Patient age was divided into 10-year interval groups: group I (030 years), group II (3140 years), group III (41 50 years), group IV (5160 years), group V (6170 years), group VI (7180 years), group VII (8190 years) and group VIII (over 90 years).
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