Akne Vulgaris Tedavisinde Topikal Niasinamid'in Etkinligi ve Güvenirligi/Efficacy and Safety of Topical Niacinamide for Acne Vulgaris

Headnote

Özet

Amaç: Bu çalismada topikal niasinamidin hafif ve orta siddetli akne vulgaris tedavisinde etkinligi ve güvenirligi ve yasam kalitesi üzerine etkisi arastirildi.

Gereç ve Yöntem: Hafif ve orta siddetli derecede aknesi olan, dermatoloji poliklinigine basvuran 29 kadin hasta çalismaya alindi. Hastalar sekiz hafta boyunca yüzlerine günde iki kez %4 niasinamid içeren krem-jel (acnecinamide-Microgen) uyguladilar. Lezyonlarin sayisi (noninsamatuvar ve insamatuvar) 0,2,4 ve 8. haftalarda sayildi. Yan etkiler (eritem, deskuamasyon yanma, ve kserozis) kaydedildi. Hastalar tedavinin basinda ve sonunda dermatolojiye özel yasam kalite ölçegi olan Skindeks-29'u tamamladi.

Bulgular: Tedavi sonunda insamatuvar lezyonlarin sayisinda azalma istatistiksel olarak anlamliydi (12,24 6,14, p=0,000). Fakat noninsamatuvar lezyonlarda tedavinin basinda ve sonundaki azalma istatistiksel olarak anlamli degildi. Niasinamid krem-jel iyi tolere edildi. Skindeks-29 skala ortalamalarinda istatistiksel olarak anlamli düzelme saglandi.

Sonuç: Topikal %4 niasinamid krem-jel hafif ve orta siddetli akne vulgaris tedavisinde alternatif tedavi olarak degerlendirilebilinir. (Türkderm 2011; 45: 93-6)

Anahtar Kelimeler: Akne vulgaris, niasinamid, yasam kalitesi

Summary

Background and Design: To investigate the efficacy and safety of topical 4% naicinamide gel cream in the treatment of mild to moderate acne vulgaris and to assess the quality of life of acne patients.

Material and Method: Twenty-nine female patients aged 16-38 (mean: 23.57±5.42) years with mild to moderate acne vulgaris who presented in dermatology outpatient clinic were enrolled in the study. All patients applied 4% niacinamide gel cream (Vivatinellacnecinamide gel cream®) on their faces twice daily for eight weeks. The number of lesions (insammatory and non-insammatory) was counted at 0, 2, 4 and 8 weeks. The side effects (erythema, desquamation, burning and dryness) were recorded. The Skindex-29, a quality-of-life measure for patients with skin disease, was administered to the subjects at the beginning and the end of treatment.

Results: The decrease in the mean number of inflammatory lesions was statistically significant at the end of the treatment (pre-treatment vs. post-treatment: 12.24 vs. 6.14; p =0.000). However, there was no statistically significant decrease in the number of non-inflammatory lesions at the end of the eight weeks. The niacinamide gel cream was generally well tolerated. There was statistically significant improvement in the Skindex-29 scale scores (p =0.000) at the end of the treatment.

Conclusion: Topical 4% niacinamide gel cream may be an alternative treatment for inflammatory lesions of mild to moderate acne vulgaris....