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AIDS Behav (2011) 15:16351646 DOI 10.1007/s10461-011-9926-x
ORIGINAL PAPER
Computer-Based Intervention in HIV Clinical Care Setting Improves Antiretroviral Adherence: The LifeWindows Project
Jeffrey D. Fisher K. Rivet Amico William A. Fisher Deborah H. Cornman
Paul A. Shuper Cynthia Trayling Caroline Redding William Barta
Anthony F. Lemieux Frederick L. Altice Kevin Dieckhaus Gerald Friedland
for the LifeWindows Team
Published online: 31 March 2011 Springer Science+Business Media, LLC 2011
Abstract We evaluated the efcacy of LifeWindows, a theory-based, computer-administered antiretroviral (ARV) therapy adherence support intervention, delivered to HIV ? patients at routine clinical care visits. 594 HIV ? adults receiving HIV care at ve clinics were
randomized to intervention or control arms. Intervention vs. control impact in the intent-to-treat sample (including participants whose ARVs had been entirely discontinued, who infrequently attended care, or infrequently used LifeWindows) did not reach signicance. Intervention impact in the On Protocol sample (328 intervention and control arm participants whose ARVs were not discontinued, who attended care and were exposed to LifeWindows regularly) was signicant. On Protocol intervention vs. control participants achieved signicantly higher levels of perfect 3-day ACTG-assessed adherence over time, with sensitivity analyses maintaining this effect down to 70% adherence. This study supports the utility of LifeWindows and illustrates that patients on ARVs who persist in care at clinical care sites can benet from adherence promotion software.
Keywords ARV Adherence Intervention
IMB-model ART
Resumen Evaluamos la ecacia de LifeWindows, una intervencin de apoyo para la adherencia a la terapia antirretroviral (TAR) basada en teora y con administracin informatizada para pacientes con VIH ? en sus visitas clnicas rutinarias. 594 adultos de cinco clnicas con VIH ? y bajo tratamiento fueron aleatoriamente asignados a un grupo de intervencin o de control. No se alcanz signicacin estadstica al comparar ambos grupos bajo la estrategia de intencin de tratar (incluyendo los participantes cuyos TAR se haban interrumpido por completo, haban asistido a la clnica en pocas ocasiones, o usaron LifeWindows con poca frecuencia). Sin embargo, la inter-vencin obtuvo un impacto signicativo cuando se evalu con la muestra bajo Protocolo (un total de 328 participantes cuyos TAR no fueron interrumpidos, asistieron a sus visitas clnicas y se expusieron a LifeWindows regularmente). Los
This article was written on behalf of the LifeWindows Team. The members of the...