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Abstract
3,5-Dihydroxy-4-i-propylstilbene (DHPS) is a compound expected to be developed into effective drugs for many inflammatory and autoimmune diseases. In order to improve the stablity of DHPS, the cross-linked chitosan (CS) microspheres loading of DHPS were prepared and characterized. The optimal conditions for preparing CS-microspheres loading of DHPS were investigated. The results showed that the CS-microspheres loading of DHPS had spherical shape with diameters between 8 and 12 microns. The entrapment of DHPS in the CS-microspheres was more than 36%. The released percentage of CS-microspheres loading of DHPS in pH 3.6 buffer solution was up to 30.9% within 96 h. In transdermal in vitro release, DHPS kept release within 60 h through rat skin and the released percentage could arrive 76.2%. The CS-microspheres loading of DHPS had excellent stability and ability of sustained release.
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1 Hebei University, College of Chemistry and Enviromental Science, Baoding, China (GRID:grid.256885.4)
2 Hebei University, College of Chemistry and Enviromental Science, Baoding, China (GRID:grid.256885.4); Hebei University of Science and Technology, School of Chemical and Pharmaceutical Engineering, Shijiazhuang, China (GRID:grid.462323.2) (ISNI:0000000418057347)
3 Hebei University of Science and Technology, School of Chemical and Pharmaceutical Engineering, Shijiazhuang, China (GRID:grid.462323.2) (ISNI:0000000418057347)