Abstract

Background

Cashew and its compounds have many important biological effects. This study is aimed at evaluating genotoxic and mutagenic effects of natural cashew nut shell liquid (nCNSL) and industrial cashew nut shell liquid (iCNSL) and a major component of iCNSL called Cardanol.

Methods

Test samples were undergone for comet assay and micronucleus tests in Swiss albino mice. Animals were orally treated with 17.37, 34.75 and 69.5 mg/kg of the test substances taking distilled water (10 mL/kg; DW) and cyclophosphamide (50 mg/kg) as negative (NC) and positive (PC) controls, respectively.

Results

The results suggest that nCNSL at 34.7 and 69.5 mg/kg and Cardanol at all tested doses induced significant genotoxic effects to the female mouse bone marrow cells, while iCNSL did not. Both nCNSL and iCNSL as well as Cardanol did not show mutagenic and cytotoxic effects. All the test samples also showed DNA repair capacity at low dose.

Conclusion

Cashew nut shell liquids and Cardanol showed genotoxic effects at high dose, but DNA repair, non-mutagenic and non-cytotoxic effects at low dose.

Details

Title
Cytogenotoxic and mutagenic profiling of cashew nut shell liquids and cardanol
Author
Leite Aracelli de Sousa 1 ; Islam, Muhammad Torequl 2   VIAFID ORCID Logo  ; Paz Márcia Fernanda Correia Jardim 1 ; Júnior Antônio Luiz Gomes 1 ; Oliveira George Laylson da Silva 1 ; Cito Antônia Maria das Graças Lopes 3 ; Melo-Cavalcante Ana Amélia de Carvalho 4 ; Lopes José Arimatéia Dantas 5 

1  Federal University of Piauí, Northeast Biotechnology Network (RENORBIO), Postgraduate Program in Pharmaceutical Sciences, Teresina, Brazil (GRID:grid.412380.c) (ISNI:0000 0001 2176 3398) 
2  Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Department of Pharmacy, Gopalganj, Bangladesh (GRID:grid.412380.c) 
3  Federal University of Piauí, Chemistry Department, CCN, Teresina, Brazil (GRID:grid.412380.c) (ISNI:0000 0001 2176 3398) 
4  Federal University of Piauí, Northeast Biotechnology Network (RENORBIO), Postgraduate Program in Pharmaceutical Sciences, Teresina, Brazil (GRID:grid.412380.c) (ISNI:0000 0001 2176 3398); Federal University of Piauí, Postgraduate Program in Pharmaceutical Sciences, Teresina, Brazil (GRID:grid.412380.c) (ISNI:0000 0001 2176 3398) 
5  Federal University of Piauí, Northeast Biotechnology Network (RENORBIO), Postgraduate Program in Pharmaceutical Sciences, Teresina, Brazil (GRID:grid.412380.c) (ISNI:0000 0001 2176 3398); Federal University of Piauí, Chemistry Department, CCN, Teresina, Brazil (GRID:grid.412380.c) (ISNI:0000 0001 2176 3398) 
Publication year
2019
Publication date
Dec 2019
Publisher
Springer Nature B.V.
e-ISSN
21991197
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/s40816-019-0129-8
ProQuest document ID
2315413952
Copyright
© The Author(s). 2019. corrected publication 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.