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Chromatographic Estimation of Niacinamide in Anti aging Dermatological product

Banik, Kabita; Rath, Simhachalam; Gupta, B K.  Asian Journal of Pharmaceutical Analysis

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Scholarly Journal

Asian Journal of Pharmaceutical Analysis

Raipur: Athena Information Solutions Pvt. Ltd.

Citation/Abstract coverage: Sep 2012 (Vol. 2, no. 3) - present

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; Raipur Vol. 9, Iss. 2,  (Jun 2019).

Kabita Banik*, Dr. Simhachalam Rath, Dr. B K Gupta

BCDA College of Pharmacy and Technology, Pharmaceutics Department, Kolkata, West Bengal

*Corresponding Author E-mail: [email protected]

ABSTRACT:

In this study Niacinamide based skin creams were formulated and evaluated. Niacinamide (also known as nicotinamide, 3-pyridinecarboxamide) is the physiologically active form of niacin or vitamin B3. Niacinamide, a derivative of niacin, has the ability to treat some skin conditions including aging skin. Quality evaluation of the product was assessed by using determination of Niacinamide content by HPTLC method and different evaluation methods. No change of the physical properties was observed; the pH was in a proper range. The formulations showed good spreadability, no evidence of phase separation and good consistency during this study period. From the present study it can be concluded that it is possible to develop creams containing Niacinamide having antiaging property and can be used as the provision of a barrier to protect skin.

KEYWORDS: Niacinamide, HPTLC, NADH and NADPH, Antiaging.

INTRODUCTION:

Niacinamide (also known as nicotinamide, 3-pyridinecarboxamide) is the physiologically active form of niacin or vitamin B3. Niacinamide, a derivative of niacin, has the ability to treat some skin conditions including aging skin. It has anti-inflammatory properties, which makes it effective for treating acne. It may also be beneficial for treating other inflammatory skin conditions such as psoriasis and rosacea. Acne is a skin condition characterized by excess sebum production and irregular shedding of dead skin cells. The dead skin cells and sebum clog hair follicles causing inflammation, which niacinamide helps to reduce. In the body, it is converted to the co-factors NADH and NADPH that are involved in many biochemical reactions. NAD+ and NADPH levels in skin cells decline with age.

Thus, supplementing skin with the precursor to these vital co-factors has the potential to provide appearance benefits to aging...