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Lavandula reduces heart injury via attenuating TNF-α and oxidative stress in a rat model of infarct-like myocardial injury

Cell Journal; Tehran Vol. 19, Iss. 1,  (Spring 2017): 84-93. DOI:10.22074/cellj.2016.4148

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Introduction

Cardiovascular diseases are becoming the main cause of mortality and morbidity around the most countries of world (1). Myocardial infarction is the most common form of heart disease. Today, traditional medicine has been more accepted by the people and modern medicine due to better understanding of the mechanisms and the impact on health and quality of life (2, 3). In recent decades, therapeutic effect of antioxidants in prevention of cardiovascular disease has been considered (4, 5). Epidemiological studies have shown that vegetables, fresh fruit or plants with rich antioxidant substances are useful in prevention of cardiovascular disease (6).

Lavender ( Lavandula angustifolia ), a member of the Labiatae family, is used for a variety of cosmetic and therapeutic purposes in herbal medicine (7, 8). Inhalation of essential oils of lavender reduced cholesterol plaques in atherosclerotic disease in rabbits, but showed no effect on serum cholesterol levels (9). Lavander showed a hypolipidemic effect in rats (10). In addition, lavender aromatherapy has displayed vasodilatory effects and enhanced coronary blood flow in human (11). Extract of lavender flower protected isolated rat hearts against ischemic reperfusion (IR) injury (12). In our recent study, lavender oil showed neuroprotective activity and antioxidant properties in an experimental model of stroke (13). In a very recent study, treatment with essential oil of lavender after MI reduced ischemic injury in rats (14). To the best of our knowledge, effects of pretreatment with lavender on myocardial ischemic injury have not been studied yet. This study aimed to investigate the effects of different doses of lavender oil and its possible mechanism in the prevention and/ or attenuation of heart damage in a rat model of infarct-like myocardial injury.

Materials and Methods Animals and drugs

In this experimental study, 65 wistar male rats (250 ± 50 g) were provided by breeding colony...