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Copyright © 2012 Patricia R. Araujo et al. Patricia R. Araujo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Translation regulation plays important roles in both normal physiological conditions and diseases states. This regulation requires cis-regulatory elements located mostly in 5[variant prime] and 3[variant prime] UTRs and trans-regulatory factors (e.g., RNA binding proteins (RBPs)) which recognize specific RNA features and interact with the translation machinery to modulate its activity. In this paper, we discuss important aspects of 5[variant prime] UTR-mediated regulation by providing an overview of the characteristics and the function of the main elements present in this region, like uORF (upstream open reading frame), secondary structures, and RBPs binding motifs and different mechanisms of translation regulation and the impact they have on gene expression and human health when deregulated.

Details

Title
Before It Gets Started: Regulating Translation at the 5[variant prime] UTR
Author
Araujo, Patricia R; Yoon, Kihoon; Ko, Daijin; Smith, Andrew D; Qiao, Mei; Uthra Suresh; Burns, Suzanne C; Penalva, Luiz O F
Publication year
2012
Publication date
2012
Publisher
John Wiley & Sons, Inc.
ISSN
15316912
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
1019758964
Copyright
Copyright © 2012 Patricia R. Araujo et al. Patricia R. Araujo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.