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Copyright © 2012 Herve Faralli and F. Jeffrey Dilworth. Herve Faralli et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Expression of the myogenin (Myog) gene is restricted to skeletal muscle cells where the transcriptional activator turns on a gene expression program that permits the transition from proliferating myoblasts to differentiating myotubes. The strict temporal and spatial regulation on Myog expression in the embryo makes it an ideal gene to study the developmental regulation of tissue-specific expression. Over the last 20 years, our knowledge of the regulation of Myog expression has evolved from the identification of the minimal promoter elements necessary for the gene to be transcribed in muscle, to a mechanistic understanding of how the proteins that bind these DNA elements work together to establish transcriptional competence. Here we present our current understanding of the developmental regulation of gene expression gained from studies of the Myog gene.

Details

Title
Turning on Myogenin in Muscle: A Paradigm for Understanding Mechanisms of Tissue-Specific Gene Expression
Author
Faralli, Herve; Dilworth, F Jeffrey
Publication year
2012
Publication date
2012
Publisher
John Wiley & Sons, Inc.
ISSN
15316912
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
1027575571
Copyright
Copyright © 2012 Herve Faralli and F. Jeffrey Dilworth. Herve Faralli et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.