Abstract

Doc number: 13

Abstract: Neurogenesis occurs in the adult hippocampus of various animal species. A substantial fraction of newly generated neurons die before they mature, and the survival rate of new neurons are regulated in an experience-dependent manner. Previous study showed that high-frequency stimulation (HFS) of perforant path fibers to the hippocampal dentate gyrus (DG) induces the long-term potentiation (LTP) in the DG, and enhances the survival of newly generated neurons in the DG. In this study, we addressed whether a time period exists during which the survival of new neurons is maximally sensitive to the HFS. We found that the enhancement of cell survival by HFS was exclusively restricted to the specific narrow period during immature stages of new neurons (7-10 days after birth). Furthermore, the pharmacological blockade of LTP induction suppressed the enhancement of cell survival by the HFS. These results suggest that the LTP induction within a narrow critical period of immature stages enhances the survival of newly generated neurons in rat DG.

Details

Title
LTP induction within a narrow critical period of immature stages enhances the survival of newly generated neurons in the adult rat dentate gyrus
Author
Kitamura, Takashi; Saitoh, Yoshito; Murayama, Akiko; Sugiyama, Hiroyuki; Inokuchi, Kaoru
Pages
13
Publication year
2010
Publication date
2010
Publisher
BioMed Central
e-ISSN
1756-6606
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/1756-6606-3-13
ProQuest document ID
1030303981
Copyright
© 2010 Kitamura et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.