Abstract

Doc number: 299

Abstract

Background: The present work was designed to evaluate the antibacterial properties of the methanol extracts of eleven selected Cameroonian spices on multi-drug resistant bacteria (MDR), and their ability to potentiate the effect of some common antibiotics used in therapy.

Results: The extract of Cinnamomum zeylanicum against Escherichia coli ATCC 8739 and AG100 strains showed the best activities, with the lowest minimal inhibitory concentration (MIC) of 64 μg/ml. The extract of Dorstenia psilurus was the most active when tested in the presence of an efflux pump inhibitor, phenylalanine Arginine-β- Naphtylamide (PAβN), a synergistic effect being observed in 56.25 % of the tested bacteria when it was combined with Erythromycin (ERY).

Conclusion: The present work evidently provides information on the role of some Cameroonian spices in the fight against multi-resistant bacteria.

Details

Title
Antibacterial and antibiotic-potentiation activities of the methanol extract of some cameroonian spices against Gram-negative multi-drug resistant phenotypes
Author
Voukeng, Igor K; Kuete, Victor; Dzoyem, Jean P; Fankam, Aimé G; Noumedem, Jaures A K; Kuiate, Jules R; Pages, Jean-Marie
Pages
299
Publication year
2012
Publication date
2012
Publisher
BioMed Central
e-ISSN
17560500
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/1756-0500-5-299
ProQuest document ID
1038815563
Copyright
© 2012 Voukeng et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.