Abstract

Doc number: 4

Abstract

Background: Prolactin (PRL) is a hormone synthesized in both the pituitary gland and extrapituitary sites. It has been associated with the occurrence of neoplasms and, more recently, with central nervous system (CNS) neoplasms. The aim of this study was to evaluate prolactin expression in primary central nervous system tumors through quantitative real-time PCR and immunohistochemistry (IH).

Results: Patient mean age was 49.1 years (SD 15.43), and females accounted for 70% of the sample. The most frequent subtype of histological tumor was meningioma (61.5%), followed by glioblastoma (22.9%). Twenty cases (28.6%) showed prolactin expression by immunohistochemistry, most of them females (18 cases, 90%). Quantitative real-time PCR did not show any prolactin expression.

Conclusions: Despite the presence of prolactin expression by IH, the lack of its expression by quantitative real-time PCR indicates that its presence in primary tumors in CNS is not a reflex of local production.

Details

Title
Prolactin gene expression in primary central nervous system tumors
Author
Mendes, Graziella Alebrant; Pereira-Lima, Júlia Fernanda Semmelmann; Kohek, Maria Beatriz; Trott, Geraldine; Di Domenico, Marlise; Ferreira, Nelson Pires; Oliveira, Miriam da Costa
Pages
4
Publication year
2013
Publication date
2013
Publisher
BioMed Central
e-ISSN
14775751
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/1477-5751-12-4
ProQuest document ID
1272124348
Copyright
© 2013 Alebrant Mendes et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.