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Copyright © 2012 Feng-Lin Yen et al. Feng-Lin Yen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Biocompatibility of sintered calcium phosphate pellets with [Ca]/[P] = 1.50 was determined in this study. Calcium pyrophosphate (CPP) phase formed on the sintered pellets immersed in a normal saline solution for 14 d at 37[composite function]C. The intensities of hydroxyapatite (HA) reflections in the X-ray diffraction (XRD) patterns of the pellets were retrieved to as-sintered state. The pellet surface morphology shows that CPP crystallites were clearly present and make an amorphous calcium phosphate (ACP) to discriminate against become to the area of slice join together. In addition, the intensities of the CPP reflections in the XRD patterns were the highest when the pellets were immersed for 28 d. When the CPP powders were extracted from the pellets after immersion in the solution for 14 d, the viability of 3T3 cells remained above 90% for culture times from 1 to 4 d. The pellet surface morphology observed using optical microscopy showed that the cells did not adhere to the bottom of the sintered pellets when cultured for 4 d; however, some CPP phase precipitates were formed, as confirmed by XRD. In consequence, the results suggest that the sintered HA powders are good materials for use in biomedical applications because of their good biocompatibility.

Details

Title
Understanding the Biocompatibility of Sintered Calcium Phosphate with Ratio of [Ca]/[P] = 1.50
Author
Feng-Lin, Yen; Wei-Jen Shih; Min-Hsiung, Hon; Hui-Ting, Chen; I-Ming, Hung; Ko, Homg-Huey; Moo-Chin, Wang
Publication year
2012
Publication date
2012
Publisher
John Wiley & Sons, Inc.
ISSN
16874110
e-ISSN
16874129
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
1272322680
Copyright
Copyright © 2012 Feng-Lin Yen et al. Feng-Lin Yen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.