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Copyright © 2013 Caio P. Fernandes et al. Caio P. Fernandes et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Manilkara subsericea(Mart.) Dubard (Sapotaceae) is popularly known in Brazil as "guracica." Studies with Manilkaraspp. indicated the presence of triterpenes, saponins, and flavonoids. Several activities have been attributed to Manilkaraspp. such as antimicrobial, antiparasitic and antitumoral, which indicates the great biological potential of this genus. In all, 87.19% of the hexanic extract from fruits relative composition were evaluated, in which 72.81% were beta- and alpha-amyrin esters, suggesting that they may be chemical markers for M. subsericea. Hexadecanoic acid, hexadecanoic acid ethyl ester, (E)-9-octadecenoic acid ethyl ester, and octadecanoic acid ethyl ester were also identified. Ethanolic crude extracts from leaves, stems, and hexanic extract from fruits exhibited antimicrobial activity against Staphylococcus aureusATCC25923. These extracts had high [subscript] IC 50[/subscript] values against Vero cells, demonstrating weak cytotoxicity. This is the first time, to our knowledge, that beta- and alpha-amyrin caproates and caprylates are described for Manilkara subsericea.

Details

Title
Triterpene Esters and Biological Activities from Edible Fruits of Manilkara subsericea(Mart.) Dubard, Sapotaceae
Author
Fernandes, Caio P; Corrêa, Arthur L; Lobo, Jonathas F R; Caramel, Otávio P; de Almeida, Fernanda B; Castro, Elaine S; Kauê F. C. S. Souza; Burth, Patrícia; Amorim, Lidia M F; Santos, Marcelo G; Ferreira, José Luiz P; Falcão, Deborah Q
Publication year
2013
Publication date
2013
Publisher
John Wiley & Sons, Inc.
ISSN
23146133
e-ISSN
23146141
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
1272337521
Copyright
Copyright © 2013 Caio P. Fernandes et al. Caio P. Fernandes et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.