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© 2012 Welsh et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Welsh RM, Bahl K, Marshall HD, Urban SL (2012) Type 1 Interferons and Antiviral CD8 T-Cell Responses. PLoS Pathog 8(1): e1002352. doi:10.1371/journal.ppat.1002352

Abstract

Type 1 IFNs get induced by viral nucleic acids and proteins acting on cellular signaling molecules such as Toll-like receptors and RNA helicases, which, in turn, release transcription factors into the nucleus. T cells that are exposed to their cognate peptide antigen presented in the context of MHC (pMHC) on APC-like dendritic cells (DCs) get costimulated through receptors such as CD28 and CD40 ligand and undergo a differentiation program associated with several cycles of division, the expression of the transcription factors t-bet and eomesodermin, followed by the acquisition of effector functions (Figure 1D).

Details

Title
Type 1 Interferons and Antiviral CD8 T-Cell Responses
Author
Welsh, Raymond M; Bahl, Kapil; Marshall, Heather D; Urban, Stina L
Pages
e1002352
Section
Opinion
Publication year
2012
Publication date
Jan 2012
Publisher
Public Library of Science
ISSN
15537366
e-ISSN
15537374
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
1289105357
Copyright
© 2012 Welsh et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Welsh RM, Bahl K, Marshall HD, Urban SL (2012) Type 1 Interferons and Antiviral CD8 T-Cell Responses. PLoS Pathog 8(1): e1002352. doi:10.1371/journal.ppat.1002352