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About the Authors:
Debby W. Tsuang
Contributed equally to this work with: Debby W. Tsuang, Steven P. Millard
* E-mail: [email protected]
Affiliations Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, United States of America, Department of Veteran Affairs, VISN-20 Mental Illness Research, Education, and Clinical Center, Seattle, Washington, United States of America
Steven P. Millard
Contributed equally to this work with: Debby W. Tsuang, Steven P. Millard
Affiliation: Department of Veteran Affairs, VISN-20 Mental Illness Research, Education, and Clinical Center, Seattle, Washington, United States of America
Benjamin Ely
Affiliation: Department of Veteran Affairs, VISN-20 Mental Illness Research, Education, and Clinical Center, Seattle, Washington, United States of America
Peter Chi
Affiliation: Department of Veteran Affairs, VISN-20 Mental Illness Research, Education, and Clinical Center, Seattle, Washington, United States of America
Kenneth Wang
Affiliation: Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, United States of America
Wendy H. Raskind
Affiliations Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, United States of America, Department of Veteran Affairs, VISN-20 Mental Illness Research, Education, and Clinical Center, Seattle, Washington, United States of America, Department of Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America
Sulgi Kim
Affiliation: Department of Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America
Zoran Brkanac
Affiliation: Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, United States of America
Chang-En Yu
Affiliations Department of Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America, Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, United States of America
Introduction
Rapidly developing technologies such as chip array-based genotyping platforms have facilitated recent large-scale interrogation of the human genome. Many of these investigations have been successful in identifying specific single nucleotide polymorphisms (SNPs) associated with complex disorders [1], [2], but these investigations cannot identify all forms of genetic variation because they focus on the common SNPs [1]. The availability of densely spaced SNPs generated by genome-wide studies has also enabled the investigation of genome structural variations, such as copy number variants (CNVs). CNVs range in size from a few to several thousand base pairs (bp), and because they frequently affect gene...