Abstract

Development and [in vitro] evaluation of buccoadhesive carvedilol tablets

Buccoadhesive tablets of carvedilol were prepared using HPMC K4M, HPMC K15M and Carbopol 934 as mucoadhesive polymers. Fifteen formulations were developed with varying concentrations of polymers. Formulations of the BC or BD series were composed of HPMC K4M or HPMC K15M in ratios of 1:1 to 1:5 whereas in the BE series Carbopol 934 was used (1:0.25 to 1:1.50). The formulations were tested for [in vitro] drug release, [in vitro] bioadhesion, moisture absorption and [in vitro] drug permeation through porcine buccal mucosa. Formulation BC3 showed maximum release of the drug (88.7 ± 0.4%) with the Higuchi model release profile and permeated 21.5 ± 2.9% of the drug (flux 8.35 ± 0.291 μg h[-1]cm[-2]) permeation coefficient 1.34 ± 0.05 cm h[-1]) through porcine buccal membrane. BC3 formulation showed 1.62 ± 0.15 N of peak detachment force and 0.24 ± 0.11 mJ of work of adhesion. FTIR results showed no evidence of interaction between the drug and polymers. XRD study revealed that the drug is in crystalline form in the polymer matrix. The results indicate that suitable bioadhesive buccal tablets with desired permeability could be prepared.

Details

Title
Development and in vitro evaluation of buccoadhesive carvedilol tablets
Author
Yamsani, Vamshi; Gannu, Ramesh; Kolli, Chandrasekhar; Rao, M; Yamsani, Madhusudan
First page
185
Publication year
2007
Publication date
Jun 2007
Publisher
De Gruyter Poland
ISSN
13300075
e-ISSN
18469558
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
1319818322
Copyright
Copyright Versita Jun 2007