Content area
Full Text
About the Authors:
Holly Janes
* E-mail: [email protected]
Affiliations Division of Vaccines and Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Biostatistics, University of Washington, Seattle, Washington, United States of America
Nicole Frahm
Affiliations Division of Vaccines and Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Global Health, University of Washington, Seattle, Washington, United States of America
Allan DeCamp
Affiliation: Division of Vaccines and Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
Morgane Rolland
Affiliation: United States Military HIV Research Program (MHRP), Rockville, Maryland, United States of America
Erin Gabriel
Affiliation: Department of Biostatistics, University of Washington, Seattle, Washington, United States of America
Julian Wolfson
Affiliation: Division of Biostatistics, University of Minnesota, Minneapolis, Minnesota, United States of America
Tomer Hertz
Affiliation: Division of Vaccines and Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
Esper Kallas
Affiliation: Division of Clinical Immunology and Allergy, University of Sao Paulo, São Paulo, São Paulo, Brazil
Paul Goepfert
Affiliation: Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
David P. Friedrich
Affiliation: Division of Vaccines and Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
Lawrence Corey
Affiliations Division of Vaccines and Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Medicine, University of Washington, Seattle, Washington, United States of America
James I. Mullins
Affiliation: Department of Microbiology, University of Washington, Seattle, Washington, United States of America
M. Juliana McElrath
Affiliations Division of Vaccines and Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Medicine, University of Washington, Seattle, Washington, United States of America
Peter Gilbert
Affiliations Division of Vaccines and Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Biostatistics, University of Washington, Seattle, Washington, United States of America
Introduction
The Step trial evaluated the efficacy of the Merck Adenovirus 5 (MRKAd5) Gag/Pol/Nef vaccine to prevent HIV-1 acquisition and reduce viral load. Three thousand high-risk HIV-1 negative individuals at 34 sites in North America, the Caribbean, South America, and Australia were randomized to vaccine or placebo. Immunizations were...