Abstract

Doc number: 43

Abstract: MicroRNAs(miRNA) are noncoding RNAs of about 19-23 nucleotides that are crucial for many biological processes. Members of the microRNA-148/152(miR-148/152) family, which include microRNA-148a(miR-148a), microRNA-148b(miR-148b), and microRNA-152(miR-152), are expressed differently in tumor and nontumor tissues and are involved in the genesis and development of disease. Furthermore, members of the miR-148/152 family are important in the growth and development of normal tissues. Members of the miR-148/152 family regulate target genes and are regulated by methylation of CPG islands. In this review, we report recent studies on the expression of members of the miR-148/152 family, methylation of CPG islands, and their target genes in different diseases, as well as in normal tissues.

Details

Title
The MicroRNA-148/152 Family: Multi-faceted Players
Author
Chen, Yue; Song, Yong-Xi; Wang, Zhen-Ning
Pages
43
Publication year
2013
Publication date
2013
Publisher
BioMed Central
e-ISSN
14764598
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/1476-4598-12-43
ProQuest document ID
1365807850
Copyright
© 2013 Chen et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.