Disparities in Oral Cancer Survival among Mentally Ill Patients

Abstract

Background

Many studies have reported excess cancer mortality in patients with mental illness. However, scant studies evaluated the differences in cancer treatment and its impact on survival rates among mentally ill patients. Oral cancer is one of the ten most common cancers in the world. We investigated differences in treatment type and survival rates between oral cancer patients with mental illness and without mental illness.

Methods

Using the National Health Insurance (NHI) database, we compared the type of treatment and survival rates in 16687 oral cancer patients from 2002 to 2006. The utilization rate of surgery for oral cancer was compared between patients with mental illness and without mental illness using logistic regression. The Cox proportional hazards model was used for survival analysis.

Results

Oral cancer patients with mental disorder conferred a grave prognosis, compared with patients without mental illness (hazard ratios [HR] = 1.58; 95% confidence interval [CI] = 1.30–1.93; P<0.001). After adjusting for patients’ characteristics and hospital characteristics, patients with mental illness were less likely to receive surgery with or without adjuvant therapy (odds ratio [OR] = 0.47; 95% CI = 0.34–0.65; P<0.001). In multivariate analysis, oral cancer patients with mental illness carried a 1.58-times risk of death (95% CI = 1.30–1.93; P<0.001).

Conclusions

Oral cancer patients with mental illness were less likely to undergo surgery with or without adjuvant therapy than those without mental illness. Patients with mental illness have a poor prognosis compared to those without mental illness. To reduce disparities in physical health, public health strategies and welfare policies must continue to focus on this vulnerable group.

About the Authors:

Ting-Shou Chang

Contributed equally to this work with: Ting-Shou Chang, Szu-Jen Hou

Affiliation: Department of Otolaryngology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan

Szu-Jen Hou

Contributed equally to this work with: Ting-Shou Chang, Szu-Jen Hou

Affiliation: Department of Otolaryngology, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan

Yu-Chieh Su

Affiliations Cancer Center, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan, Division of Hematology-Oncology, Department of Internal Medicine, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan, School of Medicine, Tzu Chi University, Hualian, Taiwan

Li-Fu Chen

Affiliation: Department of Emergency, National Yang-Ming University Hospital, Taipei, Taiwan

Hsu-Chieh Ho

Affiliations Department of Otolaryngology, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan, Cancer Center, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan, School of Medicine, Tzu Chi University, Hualian, Taiwan

Moon-Sing Lee

Affiliations Cancer Center, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan, Department of Radiation Oncology, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan, School of Medicine, Tzu Chi University, Hualian, Taiwan

Chun-Hsuan Lin

Affiliation: Department of Medical Research, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan

Pesus Chou

Affiliation: Community Medicine Research Center and the Institute of Public Health, National Yang-Ming University, Taipei, Taiwan

Ching-Chih Lee

* E-mail: [email protected]

Affiliations Department of Otolaryngology, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan, Cancer Center, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan, School of Medicine, Tzu Chi University, Hualian, Taiwan, Community Medicine Research Center and the Institute of Public Health, National Yang-Ming University, Taipei, Taiwan

Introduction

Oral cancer is among the ten most common forms of cancer in the world [1]. A trend of rising incidence has been noted on a global scale in Western countries as well as Asian countries such as Taiwan [2], [3]. Among all cancers in Taiwanese males, oral cancer which contributed 70% of head and neck cancer has been ranked fourth in incidence and mortality since 1995. It is an obvious consequence that the treatment of oral cancer makes an increasing economic burden [4], [5].

Previous reports revealed excess cancer mortality in psychiatric patients, and several possible mechanisms were proposed [6]–[8]. Patients with mental illness are associated with medical comorbidity, unemployment, living alone and low socioeconomic status [9], [10]. Due to the problems of cognitive, affective, and social manifestations, it may be hard to get complete informed consent from mentally ill patients [11]. Reduced access to general medical care and physician discretion for ordering examination may decrease the probability of full evaluation of patients with mental illness [7], [12]. High incidence of postoperative complications in patients with mental illness may further compromise the survival rates [13]. However, there is no large-scale studies which explored the receipt of medical care and survival rate among oral cancer patients with mental illness.

Although the implementation of the National Health Insurance in Taiwan in 1995 may reduce the financial barriers to access medical care for all diseases, there may be some disparities in treatment modality and long-term survival for oral cancer between patients with and without mental illness. We hypothesize here that oral cancer patients with mental illness tend to have higher risk of mortality, compared with those without mental illness. To address this hypothesis, we evaluate the association between mental illness and 5-year survival rates among oral cancer patients through the National Health Insurance Research Database (NHIRD) in Taiwan. Using a population-based data allows us to trace all medical service utilization history among oral cancer patients and measure the relationship of mental illness with oral cancer survival rates.

Materials and Methods

Ethics Statement

This study was approved by the Institutional Review Board of Buddhist Dalin Tzu Chi General Hospital, Taiwan. Review board requirements for written informed consent were waived because all personal identifying information was removed from the dataset prior to analysis.

Database

The data for this study were collected from Taiwan’s NHIRD for the years 2002 to 2006. This dataset is organized and managed by Taiwan’s National Health Research Institutes but collected by Taiwan’s National Health Insurance Program, which has been in place in Taiwan since 1995. The program covers approximately 99% of the residents in Taiwan and has contracts with 97% of the medical providers there [14]. To verify accuracy of diagnoses, Taiwan’s Bureau of National Health Insurance randomly reviews the charts of one per 100 ambulatory and one per 20 inpatient claims [15], [16].

Our cohort study consisted of Taiwan’s incidental oral cancer patients (International Classification of Diseases, Ninth Revision, Clinical Modification [ICD-9-CM] codes 140.0–145.9; malignant salivary gland tumor [ICD code 142] was excluded) who had undergone treatment from 2002 and 2006. A total of 16687 patients with oral cancer with treatment were identified. In addition, cancer staging was not known in our database and neither was smoking status.

Independent Variables

Admission ICD9-CM diagnosis identified patients with or without coexisting mental illness deemed current and ongoing at the time of initial diagnosis: (1) no mental illness, and (2) mental illness with a diagnosis of schizophrenia (ICD9-CM codes 295.00–295.99) or major affective disorder (ICD9-CM codes 296.00–296.99), or other major mental illness (ICD9-CM codes 290.00–294.99, 297.00–319.99).

Other patient characteristics contained age, gender, and severity of comorbid disease, socioeconomic status, geographic region, and urbanization of residence. The NHIRD didn’t have information on cancer staging. The disease severity of each patient was based on the Charlson Comorbidity Index score, which is widely used in recent years for risk adjustment in administrative claims data sets. We used a modified Charlson Comorbidity Index score, which is calculated as the sum of weighted scores based on the relative mortality risk of 19 conditions [17]. This study used labor enrollee category (EC) as a proxy measure of socioeconomic status (SES), which is an important prognostic factor for cancer [18], [19]. The oral cancer patients were classified into four groups: EC1 (civil servants, full-time, or regularly paid personnel with a government affiliation), EC2 (employees of privately owned institutions), EC3 (self-employed individuals, other employees, and members of the farmers’ or fishermen’s association), and EC4 (veterans, jobless families, and substitute service draftees) [20]. These patients were then further classified into three subgroups: EC1–2 (high SES), EC3 (moderate SES), and EC4 (low SES).

Geographical regions and urbanization were included. The level of urbanization was determined by population density, percentage of residents with college or higher education, percentage of residents over 65 years of age, percentage of residents who were agriculture workers, and the number of physicians per 100,000 people. The level of urbanization was assigned as urban, suburban, and rural areas [21].

The hospitals were categorized by ownership (public, non-for-profit or for-profit), and hospital accreditation level (medical center, regional or district hospital).

Dependent Variables

The key dependent variable of interest was the 5-year survival of the patients. Rates of undergoing treatment were also studied.

Statistical Analysis

The SAS statistical package (version 9.2; SAS Institute, Inc., Cary, N.C.) and SPSS (version 15, SPSS Inc., Chicago, IL, USA) were used to analyze this data. A two-sided value of P<0.05 was used to determine statistical significance.

Pearson’s chi-square tests were used to explore the differences between categorical variables. The cumulative 5-year survival rates and the survival curves were constructed with Kaplan-Meier method and compared by the log-rank test. Survival was measured from the time of the oral cancer diagnosed by using overall mortality as event variables. These patients were tracked for 5 years and further linked to the administrative data for the period 2002–2006 to estimate overall survival, with cases censored for patients who drew back guarantees from the National Health Insurance Program or were still robust without defined events at end of follow-up. A multiple logistic regression model was constructed to estimate adjusted odds ratios for differences of treatment type between oral cancer patients with and without mental illness. The Cox proportional regression model was used to evaluate the effect of mental illness on survival rates after adjusting patients’ characteristics (age, gender, Charlson Comorbidity Index Score, urbanization, area of residence and enrollee category), treatment modality (surgery with or without adjuvant therapy, and radiotherapy/chemotherapy/chemoradiotherapy) and hospital characteristics (ownership and accreditation level).

Results

Of 16687 patients, 206 (1.2%) had a secondary diagnosis of a mental illness; 174(84%) patients with other major mental disorders and 32(16%) patients with schizophrenia or other major affective disorders. The median follow-up time was 18.1 months. Table 1 shows the characteristics of the study sample according to the presence or absence of mental illness in oral cancer patients. Patients with mental illness were more likely to be younger and high socioeconomic status (P<0.001, and = 0.002; respectively). Oral cancer patients with mental illness were significantly less likely to be admitted to medical center (P = 0.004).

[Figure omitted. See PDF.]

Table 1. Characteristics of oral cancer, 2002–2006 (n = 16687).

https://doi.org/10.1371/journal.pone.0070883.t001

Figure 1 depicts the distribution of treatment modality between the two groups. After adjusting for age and gender, patients with mental illness were substantially less likely to undergo surgery with or without adjuvant therapy (odds ratio [OR] = 0.45; 95% confidence interval [CI] = 0.33–0.60; P<0.001; Table 2). After adjusting patients’ characteristics (age, gender, Charlson Comorbidity Index Score, urbanization, area of residence and enrollee category) and hospital characteristics (ownership and accreditation level), patients with mental illness remained less likely to receive surgery with or without adjuvant therapy (OR = 0.47; 95% CI = 0.34–0.65; P<0.001).

[Figure omitted. See PDF.]

Figure 1. With or without mental illness in oral cancer patients for the treatment modality.

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[Figure omitted. See PDF.]

Table 2. Use of treatment in individuals with and without mental illness (n = 16687).

https://doi.org/10.1371/journal.pone.0070883.t002

The 5-year survival rates, by presence or absence of mental illness, were illustrated in Figure 2. The 5-year survival rates were 50.5%, and 68.1% for patients with mental illness and without mental illness (P<0.001). In Cox proportional hazards models adjusted for patients’ characteristics and hospital characteristics, patients with mental illness conferred a significant increased risk for death (hazard ratios [HR] = 1.83; 95% CI, 1.50–2.23; P<0.001; Table 3). In models that additionally adjusted for treatment modality, patients with mental illness remained conferred a 1.58 times risk of death, compared to those without mental illness (HR = 1.58; 95% CI, 1.30–1.93; P<0.001).

[Figure omitted. See PDF.]

Figure 2. Survival rates in oral cancer patients with or without mental illness (n = 16687).

https://doi.org/10.1371/journal.pone.0070883.g002

[Figure omitted. See PDF.]

Table 3. Hazard ratios for 5-year overall mortality in oral cancer patients with and without mental illness (n = 16687).

https://doi.org/10.1371/journal.pone.0070883.t003

Discussion

This population-based study found that oral cancer patients with mental illness had a grave prognosis. Oral cancer patients with mental illness conferred a 1.58-times risk of mortality, compared with those without mental illness after adjusting for patient characteristics (age, gender, Charlson Comorbidity Index Score, urbanization, area of residence and enrollee category), hospital characteristics (ownership and accreditation level), and treatment modality. Patients with mental illness were substantially less likely to undergo surgery with or without adjuvant therapy. There was no significant difference in utilization of radiotherapy or chemotherapy or chemoradiotherapy in oral cancer patients with or without mental illness.

There are several possible mechanisms for poor prognosis in oral cancer patients with mental illness. Previous studies have explored that patients with mental illness were medically sicker and older, compared with patients without mental illness. Besides, oral cancer patients with severe comorbidity were associated with poor prognosis [9], [22]. In our study, mentally ill patients were more likely to be younger and from higher socioeconomic status. There was no significant difference in comorbidity severity between patients with mental illness and those without mental illness. Nevertheless, oral cancer patients with mental illness were prone to visit regional and district hospitals, which may lack the adequate facility, such as experienced head and neck surgeons, plastic surgeons, intensive care team, radiation oncologist, hematology oncologist and linear accelerator to treat oral cancer.

Oral cancer patients with mental illness were less likely to receive surgery with or without adjuvant therapy and the differences in rates of receipt of medical care between the two groups remained statistically significant in multivariate analyses that adjusted for patient characteristics, comorbidity score and hospital characteristics. Druss et al. used a large national survey in United States found that patients with mental illness tended to face particular difficulties in obtaining and maintaining both health insurance and needed medical care [12]. Although financial barriers to access medical care had been reduced after the implementation of the National Health Insurance in Taiwan in 1995, medical treatment modality remained different in mentally ill patients with either oral cancer or other disease [23]. This disparity should be of concern. Moreover, mentally ill patients are more likely to undergo postoperative complications, such as deep vein thrombosis, sepsis and respiratory failure [24]. These complications may delay the beginning of adjuvant radiotherapy or chemotherapy and cause poor prognosis for survival rates [25]. Furthermore, deteriorating psychiatric status was found more frequently in patients with mental disease [26]. Postoperative confusion, for example, may make the postoperative care more complicated and decrease the physicians’ intention to perform the surgery for oral cancer patients with mental illness.

Physician slant may exist when dealing with oral cancer patients with mental illness. One study demonstrated potential racial bias in influencing the decision of physicians to refer patients for cardiac catheterization [27]. This phenomenon may be observed among patients with mental illness in physical care [28], [29]. All the above reports indicated that potential physician bias may contribute to the difference of surgery rates in oral cancer treatment.

The reasons for excess mortality in oral cancer patients with mental illness may be associated with advanced disease and poor treatment compliance with therapy. Cognitive deficits, disorganized thinking, and impaired ability to communicate important medical symptoms may contribute to presentation at a later stage of disease [6], [30]. However, this phenomenon can’t be validated in our series due to lack of cancer staging in National Health Insurance Dataset. As regards interruption of the treatment course, such as radiotherapy or chemotherapy, may lower survival rates among mentally ill patients. Patients who had major deficiencies in treatment plans incurred a doubled risk of mortality compared with those who initially complied with treatment protocol [31], [32].

This study adds several novel points on the receipt of medical care and survival rates in oral cancer patients with or without mental illness. Using a population-based dataset enables us to trace all medical claims during the 5-year follow-up period. Previous reports presented the excess cancer mortality in psychiatric patients. However, the difference of medical care was not analyzed during these studies [6], [7]. Our study revealed the decreased access to medical treatment, especially surgery with or without adjuvant therapy among oral cancer patients with mental illness. This partly explained the poor survival rate in mentally ill patients. However, significant risk of death in patients with mental illness remained unaccounted for even in our fully adjusted model. Some unobservable variables, such as social isolation, and lack of family support may compromise the survival rates in patients with mental illness.

There are several limitations in this study. First of all, it is lack of access to detailed information from the insurance claims database with regard to oral cancer stage and pattern of relapse. These may be the important variables for increased mortality rate among cancer patients with mental illness. Delayed diagnosis or lack of access to screen in mentally ill patients might lead to more advanced staging at diagnosis and reduce possibility of surgical intervention after diagnosis. Further study is indicated using cancer registry data with more details on staging. Second, the database lacks information of lifestyle factors such as dietary habits, alcohol or tobacco use, which may be risk factors and prognostic factors for oral cancer [33]. Third, instead of cancer-specific survival rate, the overall survival rate was used, because it was not possible to determine cause-specific mortality based on this registry data. Mentally ill patients often have medical comorbidities and the direct cause of death may be another disease which susceptible to malignant neoplasm. Fourth, postoperative complication or treatment-related complications were not included. Fifth, the detail receipts of anti-psychotic drugs were not available. Given the magnitude and statistical significance of the observed effects in this study, these limitations are unlikely to compromise the results.

In summary, oral cancer patients with mental illness were substantially less likely to undergo surgery with or without adjuvant therapy than those without mental illness. Patients with mental illness conferred a poor prognosis in multivariate analysis. Oral cancer treatment for the mentally ill patients is a complex issue and deserves more concern. Meanwhile, there should be efforts to reduce disparities in physical health including oral mucosal screening during routine dental evaluations or physical examination.

Acknowledgments

This study is based in part on data from the National Health Insurance Research Database provided by the Bureau of National Health Insurance, Department of Health and managed by the National Health Research Institutes (Registered number 99018 and 101115). The interpretation and conclusions contained herein do not represent those of the Bureau of National Health Insurance, Department of Health, or National Health Research Institutes.

Author Contributions

Conceived and designed the experiments: TSC SJH LFC CCL. Analyzed the data: TSC SJH CCL. Wrote the paper: TSC SJH YCS LFC HCH MSL CHL PC CCL.

Citation: Chang T-S, Hou S-J, Su Y-C, Chen L-F, Ho H-C, Lee M-S, et al. (2013) Disparities in Oral Cancer Survival among Mentally Ill Patients. PLoS ONE 8(8): e70883. https://doi.org/10.1371/journal.pone.0070883

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