Abstract

Introduction: The role of vascular endothelial growth factor (VEGF) in osteoporosis has not yet been clearly established. Vascular endothelial growth factor is an important part of bone formation. In the literature, although the effects of VEGF on bone metabolism were investigated by different studies, there are very rare studies analysing the association between osteoporosis and VEGF. In the present study, our objective was to investigate serum VEGF concentrations in patients with postmenopausal osteoporosis (PMO) and the correlation of serum VEGF levels and bone mineral density (BMD).

Material and methods: This study was performed on 35 PMO patients, and 30 age-matched healthy controls. Serum VEGF concentrations were measured using a quantitative sandwich enzyme immunoassay technique according to the manufacturer's instructions. Bone mineral density values were determined by dual energy X-ray absorptiometry (DEXA).

Results: Serum VEGF concentrations were statistically significantly lower in PMO patients than in controls (150 ±65 pg/ml, 260 ±135 pg/ml respectively; p = 0.005). A positive correlation was found between serum VEGF concentrations and BMD values (r = 0.63, p = 0.001).

Conclusions: Vascular endothelial growth factor concentrations were decreased in PMO patients and VEGF may play an important role in bone health.

Details

Title
Clinical research: Circulating vascular endothelial growth factor concentrations in patients with postmenopausal osteoporosis
Author
Senel, Kazim; Baykal, Tuba; Seferoglu, Buminhan; Altas, Elif Umay; Baygutalp, Fatih; Mahir Ugur; Kiziltunc, Ahmet
First page
709
Publication year
2013
Publication date
2013
Publisher
Termedia Publishing House
ISSN
17341922
e-ISSN
18969151
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
1431943334
Copyright
Copyright Termedia Publishing House 2013