ARTICLES
Trypanosomiasis cruzi: a follow-up study of tissue reacting immunoglobulins in infected purebred pinscher dogs
Eduardo Alves BambirraI; Washington Luis TafuriI; Luigi Bogliolo§; Cléa ChiariII; Fausto Edmundo Lima PereiraIII
ITrabalho dos Departamentos de Anatomia Patológica e Medicina Legal da Faculdade de Medicina da Universidade Federal de Minas Gerais
IIde Parasitologia do Instituto de Ciências Biológicas da Universidade Federal de Minas Gerais
IIIde Patologia da Universidade Federal do Espírito Santo
§"In memoriam"
Adress to correspondence
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ABSTRACT
Antibodies against striated muscle (cardiac and skeletal) were studied in serum samples from 36 purebred prepubertal Pinscher dogs (15 Controls without infection and 21 infected with Trypanosoma cruzi from 7 to 400 days after infection with 1000 trypomastigotes/gram body weight of the Colombiana strain by the intraperitoneal route). Although three different immunohistological pattems of tissue-reacting immunoglobulins were found their presence was not correlated with any peculiar characteristics or with the severity of the disease in each particular dog.
Keywords: Experimental trypanosomiasis cruzi. Dog. Autoantibodies. Tissue-reacting immunoglobulins.
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RESUMO
Foi investigada a presença de anticorpos contra músculo estriado (cardíaco e esquelético) em amostras de soro de 36 cães Pinscher de raça pura, pré-púberes (15 controles sem infecção e 21 infectados com Trypanosoma cruzi). A infecção foi feita através de injeção intraperitoneal de 1.000 tripomastigotas/grama de peso e os cães foram examinados entre os dias 7 e 400. Três diferentes padrões de distribuição de imunoglobulinas nos tecidos foram demonstrados, embora não pudessem ser correlacionados com a característica da infecção ou com a gravidade da doença nos diferentes cães.
Palavras-chave: Doença de Chagas experimental. Cães. Auto-anticorpos. Imunoglobulinas em tecidos.
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REFERENCES
1. Abrahamsohn JA, Kloetzel JK. Presence of Trypanosoma cruzi antigen on the surface of both infected and uninfected cells in tissue culture. Parasitology 80: 147- 152, 1980. [ Links ]
2. Bambirra EA. Infecção experimental de cães Pinscher pelo Trypanosoma cruzi (Chagas, 1909): resposta imunitária ao parasita, a antígenos exógenos e de tecidos do hospedeiro, no decurso da evolução. Tese de doutorado. Universidade Federal de Minas Gerais, Belo Horizonte, 1982. [ Links ]
3. Brener Z. Immunity to Trypanosoma cruzi. Advances in Parasitology 18: 247-292, 1980. [ Links ]
4. Chagas C. Nova trypanosomíase humana. Ensaios sobre a morfologia e o ciclo evolutivo do R. prolixus n.gen., n. sp. ajente etiolojico de nova entidade mórbida do homem. Memórias do Instituto Oswaldo Cruz 1: 159- 218, 1909. [ Links ]
5. Cossio PM, Diez C, Szarfman A, Kreutzer E, Candiolo B, Arana RM. Chagasic cardiopathy: demonstration of a serum gamma globulin factor which reacts with endocardium and vascular structures. Circulation 49: 13-21, ' 1974. [ Links ]
6. Costa JF, Costa A. Verificações experimentais sobre imunidade humoral na doença de Chagas. Publicações Médicas (São Paulo) 31: 29-37, 1980. [ Links ]
7. Muniz J, Soares R, Quiroga L, Batista S. Evolução da imunidade humoral em cães infectados experimentalmente pelo R. prolixus. Revista Brasileira de Malaríologia e Doenças Tropicais 5: 197-200, 1953. [ Links ]
8. Ribeiro dos Santos R, Hudson L. Trypanosoma cruzi: binding of parasite antigers to mammalian cell membranes: Parasite Immunology 2: 1-10, 1980. [ Links ]
9. Santos-Buch CA, Teixeira ARL. The immunology of experimental Chagas' disease. III-Rejection of allogenic heart cells "in vitro". Journal of Experimental Medicine 140: 38-53, 1974. [ Links ]
10. Szarfman A, Cossio PM, Laguens RP, De la Vega MT, Arana RM, Schmunis GA. Immunological studies in Rockland mice infected with Trypanosoma cruzi. Development of anti-nuclear antibodies. Biomedicine 22: 489-495, 1975. [ Links ]
11. Szarfman A, Gerecht P, Draper CC, Marsden PD. Tissue-reacting immunoglobulins in Rhesus monkeys infected with Trypanosoma cruzi: a follow-up study. Transactions of the Royal Society for Tropical Medicine and Hygiene 75: 114-118, 1981. [ Links ]
12. Teixeira ARL, Teixeira L, Santos-Buch CA. The immunology of experimental Chagas' disease in man. American Journal of Pathology 80: 163-178, 1975. [ Links ]
Adress to correspondence:
Dr. Bambirra
R Turmalina, 274
Prado
CEP 30 000
Belo Horizonte - MG.
Recebido para publicação em 5/9/1983.
Trabalho realizado com auxílio do CNPq e da FINEP.
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Copyright Sociedade Brasileira de Medicina Tropical Oct/Dec 1984
Abstract
Antibodies against striated muscle (cardiac and skeletal) were studied in serum samples from 36 purebred prepubertal Pinscher dogs (15 Controls without infection and 21 infected with Trypanosoma cruzi from 7 to 400 days after infection with 1000 trypomastigotes/gram body weight of the Colombiana strain by the intraperitoneal route). Although three different immunohistological pattems of tissue-reacting immunoglobulins were found their presence was not correlated with any peculiar characteristics or with the severity of the disease in each particular dog.
You have requested "on-the-fly" machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Show full disclaimer
Neither ProQuest nor its licensors make any representations or warranties with respect to the translations. The translations are automatically generated "AS IS" and "AS AVAILABLE" and are not retained in our systems. PROQUEST AND ITS LICENSORS SPECIFICALLY DISCLAIM ANY AND ALL EXPRESS OR IMPLIED WARRANTIES, INCLUDING WITHOUT LIMITATION, ANY WARRANTIES FOR AVAILABILITY, ACCURACY, TIMELINESS, COMPLETENESS, NON-INFRINGMENT, MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. Your use of the translations is subject to all use restrictions contained in your Electronic Products License Agreement and by using the translation functionality you agree to forgo any and all claims against ProQuest or its licensors for your use of the translation functionality and any output derived there from. Hide full disclaimer