Abstract

Two women in their 60's are presented to us with sudden falls of acute onset. Prolonged observation revealed a gradually evolving syndrome of paroxysmal right sided faciobrachial dystonic (FBD) posturing lasting seconds. Both patients went on to develop hyponatremia, following which the episodes worsened and appeared on both sides. In both cases, prolonged electroencephalography monitoring and magnetic resonance imaging brain were normal and the response to conventional anticonvulsants was poor. One patient improved spontaneously over 6 months. The 2 nd patient developed an amnestic syndrome and was started on intravenous methylprednisolone with which her movement disorder abated. Her amnestic syndrome improved and she was discharged on oral steroids. Both patients tested positive for leucine-rich glioma inactivated 1 (LGi1) antibodies. We present the first case reports of FBD episodes and drop attacks owing to LGi1 encephalitis from India and review the relevant literature pertinent to the subject.

Details

Title
Facio-brachio-crural dystonic episodes and drop attacks due to leucine rich glioma inactivated 1 encephalitis in two elderly Indian women
Author
Maramattom, Boby; Jeevanagi, Sachin; George, Celinamma
Pages
590-592
Publication year
2013
Publication date
Oct-Dec 2013
Publisher
Medknow Publications & Media Pvt. Ltd.
ISSN
09722327
e-ISSN
19983549
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
1450022582
Copyright
Copyright Medknow Publications & Media Pvt Ltd Oct-Dec 2013