Abstract

Doc number: 102

Abstract: Plant-based compounds have been in the spotlight in search of new and promising drugs. Flavokawain A, B and C are naturally occurring chalcones that have been isolated from several medicinal plants; namely the piper methysticum or commercially known as the kava-kava. Multiple researches have been done to evaluate the bioactivities of these compounds. It has been shown that all three flavokawains may hold promising anti-cancer effects. It has also been revealed that both flavokawain A and B are involved in the induction of cell cycle arrest in several cancer cell lines. Nevertheless, flavokawain B was shown to be more effective in treating in vitro cancer cell lines as compared to flavokawain A and C. Flavokawain B also exerts antinociceptive effects as well as anti-inflammation properties. This mini-review attempts to discuss the biological properties of all the flavokawains that have been reported.

Details

Title
The flavokawains: uprising medicinal chalcones
Author
Abu, Nadiah; Ho, Wan Yong; Yeap, Swee Keong; Akhtar, M Nadeem; Abdullah, Mohd Puad; Omar, Abdul Rahman; Alitheen, Noorjahan Banu
Publication year
2013
Publication date
2013
Publisher
BioMed Central
e-ISSN
14752867
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/1475-2867-13-102
ProQuest document ID
1454881960
Copyright
© 2013 Abu et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.